Milosavljević T, Trbojević B, Adanja G, Lalić M, Devecerski M
University Clinical Centre, Belgrade, Yugoslavia, Digestive Diseases Institute.
Mater Med Pol. 1989 Jul-Sep;21(3):223-4.
Conflicting reports exist on the postprandial response of serum cationic trypsin like immunoreactivity (SCTLI). The purpose of the current study was to examine the postprandial response of SCTLI in healthy persons and in insulin dependent diabetes mellitus (IDDM) patients and relate this to C-peptide secretion. The study was performed on six healthy males 25-40 years old and in nine male IDDM patients 25-38 years old. To all the patients after an overnight fast was given a standardized breakfast. Blood samples were obtained through a butterfly needle inserted into the antecubital vein at 0, 30, 60 and 120 minutes. Radioimmunoassays were performed using commercially available kits: for SCTLI CIS-SORIN and for C-peptide BIODATA. In healthy persons there was a significant rise of SCTLI concentration at 30 minutes, and C-peptide at 30 and 60 minutes. IDDM patients showed lower basal levels of SCTLI and C-peptide, without any significant changes of SCTLI and C-peptide during the test. We concluded that trypsin appearance in serum closely correlates with endocrine pancreatic function.
关于血清阳离子胰蛋白酶样免疫反应性（SCTLI）的餐后反应存在相互矛盾的报道。本研究的目的是检测健康人和胰岛素依赖型糖尿病（IDDM）患者中SCTLI的餐后反应，并将其与C肽分泌相关联。该研究对6名25至40岁的健康男性和9名25至38岁的男性IDDM患者进行。在禁食过夜后，给所有患者提供标准化早餐。通过插入肘前静脉的蝶形针在0、30、60和120分钟时采集血样。使用市售试剂盒进行放射免疫测定：用于SCTLI的CIS-SORIN试剂盒和用于C肽的BIODATA试剂盒。在健康人中，SCTLI浓度在30分钟时显著升高，C肽在30和60分钟时显著升高。IDDM患者的SCTLI和C肽基础水平较低，在测试期间SCTLI和C肽没有任何显著变化。我们得出结论，血清中胰蛋白酶的出现与胰腺内分泌功能密切相关。
