Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Medical Research Collaborating Center, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Ophthalmology. 2014 Oct;121(10):1933-8. doi: 10.1016/j.ophtha.2014.04.029. Epub 2014 Jun 7.
To define the incidence and demographics of clinically diagnosed central retinal artery occlusion (CRAO) in Korea.
Nationwide population-based retrospective study using data entered into the Korean national health claims database from 2007 to 2011.
Data of the entire Korean population (N = 47,990,761, based on the 2010 census) were analyzed.
We used the national health claims database to identify patients diagnosed with CRAO. Incident cases were those with no claims related to CRAO in 2007 and were included once on the earliest claims related to CRAO in the years 2008 to 2011. Incident cases had a disease-free period before diagnosis of at least 1 to 4 years. The average incidence rate of CRAO was estimated according to the entire Korean population.
The person-time incidence rates of clinically diagnosed CRAO in Korea, including the age- and sex-specific incidence rates, were estimated.
A total of 3464 CRAO cases (59.1% men) were identified. The incidence rate of clinically diagnosed CRAO during the study period was 1.80 per 100,000 person-years (95% confidence interval [CI], 1.74-1.86). The incidence rate among men and women was 2.15 (95% CI, 2.05-2.24) and 1.47 (95% CI, 1.39-1.54) per 100,000 person-years (male-to-female ratio, 1.47), respectively. The age-specific male-to-female ratios were constant between the ages of 30 and 89 years (range, 1.51-2.10 years). The highest incidence of 10.08 (95% CI, 8.80-11.35) per 100,000 person-years was observed in those aged 80 to 84 years (14.65 [95% CI, 11.90-17.40] and 8.00 [95% CI, 6.63-9.37] per 100,000 person-years for men and women aged 80-84 years, respectively). The incidence rate of CRAO increased exponentially with age until the 9th decade of life.
To our knowledge, this is the first nationwide epidemiologic study of CRAO in individuals of all ages. The incidence rate of CRAO in Korea increased exponentially with increasing age and was highest among those aged 80 to 84 years. Moreover, the incidence rate in men was 1.47 times higher than that in women.
定义韩国临床诊断的中央视网膜动脉阻塞（CRAO）的发病率和人口统计学特征。
使用 2007 年至 2011 年输入韩国国家健康索赔数据库的数据进行的全国性基于人群的回顾性研究。
分析了全体韩国人口（N=47990761，基于 2010 年人口普查）的数据。
我们使用国家健康索赔数据库来识别被诊断为 CRAO 的患者。发病病例是指在 2007 年没有与 CRAO 相关的索赔记录，并且在 2008 年至 2011 年期间首次记录与 CRAO 相关的索赔。发病病例在诊断前至少有 1 至 4 年的无疾病期。根据全体韩国人口，估计 CRAO 的平均发病率。
估计韩国临床诊断 CRAO 的时点发病率，包括年龄和性别特异性发病率。
共确定了 3464 例 CRAO 病例（59.1%为男性）。研究期间 CRAO 的发病率为每 100000 人年 1.80 例（95%置信区间[CI]，1.74-1.86）。男性和女性的发病率分别为每 100000 人年 2.15（95%CI，2.05-2.24）和 1.47（95%CI，1.39-1.54）（男/女比值，1.47）。30 至 89 岁之间，特定年龄的男性/女性比值保持不变（范围，1.51-2.10 岁）。发病率最高为每 100000 人年 10.08 例（95%CI，8.80-11.35），见于 80 至 84 岁年龄组（14.65[95%CI，11.90-17.40]和 8.00[95%CI，6.63-9.37]，男性和女性 80-84 岁的发病率分别为每 100000 人年）。CRAO 的发病率随年龄呈指数增长，直到生命的第 9 个十年。
据我们所知，这是首次对所有年龄段人群 CRAO 的全国性流行病学研究。韩国 CRAO 的发病率随年龄的增长呈指数增长，在 80 至 84 岁年龄组中发病率最高。此外，男性的发病率是女性的 1.47 倍。
