Chuang Shu-Han, Chang Cheng-Hsien
Division of General Practice, Department of Medical Education, Changhua Christian Hospital, Changhua, Taiwan.
Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan.
Graefes Arch Clin Exp Ophthalmol. 2025 Jan;263(1):47-57. doi: 10.1007/s00417-024-06594-8. Epub 2024 Aug 14.
The goal of this meta-analysis is to examine the association between Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in patients with Retinal Artery Occlusion (RAO). The analysis aims to provide insight into the potential of NLR and PLR as inflammatory biomarkers for RAO.
Following PRISMA guidelines, a systematic search in PubMed, Embase, and Scopus identified eight eligible studies. The analysis assessed serum NLR and PLR levels in RAO and non-RAO groups by employing standardized mean differences (SMDs). Sensitivity analyses and publication bias were examined. The diagnostic performance of these markers was evaluated with a quantitative synthesis.
The meta-analysis, involving 1,444 participants, demonstrated significantly elevated NLR (SMD = 0.88, 95% CI: 0.49-1.28, P < 0.001) and PLR (SMD = 0.45, 95% CI: 0.16-0.73, P < 0.001) levels in individuals with RAO. Significant heterogeneity was noted. Sensitivity analysis showed robustness and no significant publication bias was found. Summary results of diagnostic performance revealed promising discriminatory power for NLR and PLR.
The results support a possible connection between systemic inflammation, as indicated by NLR and PLR, and the occurrence of RAO. Although there was heterogeneity, sensitivity analyses showed the findings to be robust. While immediate diagnostic applications are limited, understanding the role of NLR and PLR in the pathological process of RAO provides valuable insights for developing future predictive models, risk management approaches, and treatment strategies. Further research exploring mechanistic insights and conducting prospective studies is warranted to validate their clinical utility.
What is known Retinal artery occlusion (RAO) is a serious condition with potential links to systemic inflammation and thrombosis. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are emerging inflammatory markers. What is new This is the first meta-analysis examining the association between NLR, PLR and RAO. Elevated NLR and PLR levels were observed in patients with RAO compared to controls. NLR and PLR show potential as indicators of systemic inflammation in RAO pathogenesis.
本荟萃分析的目的是研究视网膜动脉阻塞（RAO）患者中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）之间的关联。该分析旨在深入了解NLR和PLR作为RAO炎症生物标志物的潜力。
按照PRISMA指南，在PubMed、Embase和Scopus中进行系统检索，确定了八项符合条件的研究。该分析采用标准化均数差（SMD）评估RAO组和非RAO组的血清NLR和PLR水平。进行了敏感性分析和发表偏倚检验。通过定量综合评估这些标志物的诊断性能。
该荟萃分析涉及1444名参与者，结果显示RAO患者的NLR（SMD = 0.88，95%CI：0.49 - 1.28，P < 0.001）和PLR（SMD = 0.45，95%CI：0.16 - 0.73，P < 0.001）水平显著升高。存在显著异质性。敏感性分析显示结果稳健，未发现显著的发表偏倚。诊断性能的汇总结果显示NLR和PLR具有良好的鉴别能力。
结果支持NLR和PLR所表明的全身炎症与RAO发生之间可能存在联系。尽管存在异质性，但敏感性分析显示结果可靠。虽然目前直接的诊断应用有限，但了解NLR和PLR在RAO病理过程中的作用为开发未来的预测模型、风险管理方法和治疗策略提供了有价值的见解。有必要进一步开展研究以探索其机制并进行前瞻性研究，以验证它们的临床效用。
已知信息视网膜动脉阻塞（RAO）是一种严重疾病，与全身炎症和血栓形成可能存在关联。中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）是新兴的炎症标志物。新发现这是第一项研究NLR、PLR与RAO之间关联的荟萃分析。与对照组相比，RAO患者的NLR和PLR水平升高。NLR和PLR在RAO发病机制中显示出作为全身炎症指标的潜力。
