Mainous Arch G, Tanner Rebecca J, Baker Richard, Zayas Cilia E, Harle Christopher A
Department of Health Services Research Management, and Policy, University of Florida, Gainesville, Florida, USA.
BMJ Open. 2014 Jun 9;4(6):e005002. doi: 10.1136/bmjopen-2014-005002.
Prediabetes is a high-risk state for developing diabetes and associated complications. The purpose of this paper was to report trends in prevalence of prediabetes for individuals aged 16 and older in England without previously diagnosed diabetes.
Data collected by the Health Survey for England (HSE) in England in the years 2003, 2006, 2009 and 2011.
Individuals aged 16 and older who participated in the HSE and provided a blood sample.
Individuals were classified as having prediabetes if glycated haemoglobin was between 5.7% and 6.4% and were not previously diagnosed with diabetes.
The prevalence rate of prediabetes increased from 11.6% to 35.3% from 2003 to 2011. By 2011, 50.6% of the population who were overweight (body mass index (BMI)>25) and ≥40 years of age had prediabetes. In bivariate relationships, individuals with greater socioeconomic deprivation were more likely to have prediabetes in 2003 (p=0.0008) and 2006 (p=0.0246), but the relationship was not significant in 2009 (p=0.213) and 2011 (p=0.3153). In logistic regressions controlling for age, sex, race/ethnicity, BMI and high blood pressure, the second most socioeconomically deprived had a significantly elevated risk of having prediabetes (2011, OR=1.45; 95% CI 1.26 to 1.88).
There has been a marked increase in the proportion of adults in England with prediabetes. The socioeconomically deprived are at substantial risk. In the absence of concerted and effective efforts to reduce risk, the number of people with diabetes is likely to increase steeply in coming years.
糖尿病前期是发生糖尿病及相关并发症的高危状态。本文旨在报告英格兰16岁及以上既往未诊断糖尿病个体的糖尿病前期患病率趋势。
数据由2003年、2006年、2009年和2011年英格兰健康调查（HSE）收集。
参与HSE并提供血样的16岁及以上个体。
糖化血红蛋白在5.7%至6.4%之间且既往未诊断糖尿病的个体被分类为患有糖尿病前期。
2003年至2011年，糖尿病前期患病率从11.6%增至35.3%。到2011年，超重（体重指数（BMI）>25）且年龄≥40岁的人群中有50.6%患有糖尿病前期。在双变量关系中，社会经济剥夺程度较高的个体在2003年（p = 0.0008）和2006年（p = 0.0246）更易患糖尿病前期，但在2009年（p = 0.213）和2011年（p = 0.3153）这种关系不显著。在控制年龄、性别、种族/民族、BMI和高血压的逻辑回归中，社会经济剥夺程度第二高的个体患糖尿病前期的风险显著升高（2011年，比值比=1.45；95%置信区间1.26至1.88）。
英格兰患有糖尿病前期的成年人比例显著增加。社会经济剥夺人群面临重大风险。若不采取协调一致的有效措施降低风险，未来几年糖尿病患者数量可能会急剧增加。
