Simsek Yavuz, Gul Mehmet, Yilmaz Ercan, Ozerol Ibrahim Halil, Ozerol Elif, Parlakpinar Hakan
Department of Obstetrics and Gynecology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey,
Arch Gynecol Obstet. 2014 Nov;290(5):999-1006. doi: 10.1007/s00404-014-3295-4. Epub 2014 Jun 10.
The purpose of this study was to examine the effects of atorvastatin in the treatment of experimental endometriosis.
Endometriosis was induced in 24 female rats. 4 weeks after the procedure dimensions of the foci were recorded. Rats were divided into three groups: in Group 1 (n = 8), a daily dose of 10 mg/kg atorvastatin was given for 14 days. In the second group (n = 8), a single dose of 1 mg/kg leuprolide acetate was injected intraperitoneally. The rats in Group 3 (n = 8) were received 1 mg/kg i.p. 0.9 % NaCl. At the end of the treatment, laparotomy was performed, and the dimensions of the endometriotic foci were recorded. Biochemical, histopathological and immunohistochemical studies were performed and nociception was compared in groups.
Atorvastatin treatment exhibited significant analgesic activity in hot plate model (P = 0.022). The serum hs-CRP and tumor necrosis TNF-α levels were similar between the Group 2 and Group 3 (P > 0.05); however atorvastatin caused significant decrease in both serum markers. The histological and immunohistochemical scores were also found to be markedly lower in Group 1 and Group 2 (P < 0.05).
Atorvastatin treatment may have a therapeutic potential in the treatment of endometriosis through its anti-inflammatory and anti-nociceptive properties.
本研究旨在探讨阿托伐他汀对实验性子宫内膜异位症的治疗效果。
对24只雌性大鼠诱导产生子宫内膜异位症。手术4周后记录病灶大小。将大鼠分为三组：第1组（n = 8），每日给予10 mg/kg阿托伐他汀，持续14天。第二组（n = 8），腹腔注射1 mg/kg醋酸亮丙瑞林单次剂量。第3组（n = 8）大鼠腹腔注射1 mg/kg 0.9%氯化钠。治疗结束时，进行剖腹手术，记录子宫内膜异位病灶大小。进行生化、组织病理学和免疫组织化学研究，并比较各组的痛觉感受。
在热板模型中，阿托伐他汀治疗表现出显著的镇痛活性（P = 0.022）。第2组和第3组之间血清hs-CRP和肿瘤坏死因子TNF-α水平相似（P > 0.05）；然而，阿托伐他汀使两种血清标志物均显著降低。第1组和第2组的组织学和免疫组织化学评分也明显较低（P < 0.05）。
阿托伐他汀治疗可能因其抗炎和抗痛觉感受特性而在子宫内膜异位症治疗中具有治疗潜力。
