Chelvam P, Goh K L, Leong Y P, Leela M P, Yin T P, Ahmad H, Jalleh R, Wong N W, Lee H B, Mahendran T
Kelinik Panir, Kuala Lumpur, Malaysia.
J Gastroenterol Hepatol. 1989;4 Suppl 2:53-61.
A double-blind randomized study in 230 Malaysian patients with duodenal ulcer was conducted to compare the proton-pump inhibitor, omeprazole 20 mg, given once daily in the morning, with ranitidine 300 mg, administered once daily at night. After 2 and 4 weeks of treatment, 222 and 220 patients, respectively, were evaluable according to the study protocol. Omeprazole produced significantly higher healing rates than ranitidine at both 2 weeks (75% versus 46%, respectively, P less than 0.0001) and 4 weeks (97% versus 83%, respectively, P = 0.001). Ulcer symptoms were relieved more rapidly by omeprazole than ranitidine. After 2 weeks, daytime epigastric pain was reported by 30% of ranitidine-treated patients but only by 15% of omeprazole-treated patients, which is a statistically significant difference (P = 0.004). No major clinical or biochemical side effects were recorded for either omeprazole or ranitidine. In conclusion, omeprazole 20 mg was found to be superior to ranitidine 300 mg administered once daily for the treatment of duodenal ulcer as measured by ulcer healing and pain relief.
一项针对230名马来西亚十二指肠溃疡患者的双盲随机研究开展，旨在比较每日早晨服用一次的质子泵抑制剂奥美拉唑20毫克与每晚服用一次的雷尼替丁300毫克。按照研究方案，治疗2周和4周后，分别有222名和220名患者可进行评估。在2周时（分别为75%和46%，P<0.0001）以及4周时（分别为97%和83%，P = 0.001），奥美拉唑产生的愈合率均显著高于雷尼替丁。奥美拉唑缓解溃疡症状的速度比雷尼替丁更快。2周后，雷尼替丁治疗组有30%的患者报告有日间上腹部疼痛，而奥美拉唑治疗组只有15%的患者报告有此症状，这是一个具有统计学意义的差异（P = 0.004）。奥美拉唑和雷尼替丁均未记录到重大临床或生化副作用。总之，就溃疡愈合和疼痛缓解情况而言，发现每日服用一次的20毫克奥美拉唑优于300毫克雷尼替丁用于治疗十二指肠溃疡。
