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An open trial on short-term omeprazole therapy for gastric and duodenal ulcers.

作者信息

Sollano J D, Espiritu A C, Alvarez S Z, Perez J Y

机构信息

University of Santo Tomas, Manila, Philippines.

出版信息

Gastroenterol Jpn. 1991 Jul;26 Suppl 3:271-4. doi: 10.1007/BF02779319.

DOI:10.1007/BF02779319
PMID:1884955
Abstract

Omeprazole, a proton pump inhibitor, is a potent and long-acting gastric acid reducing agent. To assess its short-term efficacy and safety, 27 gastric ulcers (GU) and 40 duodenal ulcers (DU) in 64 patients were treated with 20 mg. Omeprazole was given once daily. At 2 weeks, the healing rate for gastric ulcers was 66% (18/27) and for duodenal ulcers, 78% (31/40). At 4 weeks, the healing rate was 85% and 95% for GU and DU, respectively. Pain relief was achieved after 2 weeks in 62% with GU and 61% in DU. There were no significant side effects noted during the treatment course. Omeprazole is effective and safe in the treatment of gastric and duodenal ulcers.

摘要

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本文引用的文献

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Effect of omeprazole and cimetidine on duodenal ulcer. A double-blind comparative trial.奥美拉唑与西咪替丁对十二指肠溃疡的疗效。一项双盲对照试验。
N Engl J Med. 1985 Apr 11;312(15):958-61. doi: 10.1056/NEJM198504113121505.
2
Omeprazole (20 mg daily) versus cimetidine (1200 mg daily) in duodenal ulcer healing and pain relief.奥美拉唑（每日20毫克）与西咪替丁（每日1200毫克）用于十二指肠溃疡愈合和缓解疼痛的比较。
Gastroenterology. 1988 May;94(5 Pt 1):1130-4. doi: 10.1016/0016-5085(88)90003-0.
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Omeprazole vs. ranitidine in the short-term treatment of duodenal ulcer: an Italian multicenter study.
奥美拉唑与雷尼替丁治疗十二指肠溃疡的短期疗效比较：一项意大利多中心研究。
Hepatogastroenterology. 1987 Oct;34(5):229-32.
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Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer.奥美拉唑和雷尼替丁对良性胃溃疡患者溃疡愈合及复发率的影响。
N Engl J Med. 1989 Jan 12;320(2):69-75. doi: 10.1056/NEJM198901123200201.
5
Evaluation of omeprazole as a treatment for gastric and prepyloric ulcer in Korean patients.奥美拉唑治疗韩国患者胃溃疡和幽门管溃疡的疗效评估。
J Gastroenterol Hepatol. 1989;4 Suppl 2:69-74.
6
Omeprazole 20 mg and 40 mg daily in the treatment of gastric ulcer: a pilot study in Filipino patients.奥美拉唑每日20毫克和40毫克治疗胃溃疡：菲律宾患者的一项初步研究。
J Gastroenterol Hepatol. 1989;4 Suppl 2:63-8.
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Omeprazole compared with ranitidine once daily in the treatment of duodenal ulcer.奥美拉唑与雷尼替丁每日一次治疗十二指肠溃疡的比较。
J Gastroenterol Hepatol. 1989;4 Suppl 2:53-61.
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Omeprazole or cimetidine once daily for the treatment of duodenal ulcers?
J Gastroenterol Hepatol. 1989;4 Suppl 2:45-52.
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Omeprazole and ranitidine in duodenal ulcer healing and subsequent relapse: a randomized double-blind study with weekly endoscopic assessment.
J Gastroenterol Hepatol. 1989;4 Suppl 2:35-43.
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Omeprazole provides quicker symptom relief and duodenal ulcer healing than ranitidine.奥美拉唑比雷尼替丁能更快地缓解症状和治愈十二指肠溃疡。
Gastroenterology. 1990 Feb;98(2):278-83. doi: 10.1016/0016-5085(90)90815-i.