Barbara L, Blasi A, Cheli R, Corinaldesi R, Dobrilla G, Francavilla A, Rinetti M, Vezzaldini P, Abbiati R, Gradnik R
Istituto di Clinica Medica e Gastroenterologia, Università di Bologna.
Hepatogastroenterology. 1987 Oct;34(5):229-32.
A double-blind, double-dummy, randomized Italian multicenter trial was carried out to compare the efficacy and safety of omeprazole 20 mg in the morning and ranitidine 150 mg b.i.d. in short-term treatment of acute duodenal ulcer. One hundred and twenty-one patients (61 in the omeprazole and 60 in the ranitidine group) with endoscopically proven active duodenal ulcer, completed the study. The healing rates after 2, 4 and 6 weeks were 66, 97 and 100%, respectively, with omeprazole and 53, 85 and 92%, respectively, with ranitidine. The difference was statistically significant (p less than 0.05) at weeks 4 and 6. Night and day pain were markedly reduced during both treatments, as also antacid consumption. Both drugs were well tolerated, and the adverse events were infrequent and moderate. In our experience, omeprazole 20 mg once daily seems to be superior to ranitidine 150 mg b.i.d. in the short-term treatment of duodenal ulcer.
一项双盲、双模拟、随机的意大利多中心试验开展，以比较早晨服用20毫克奥美拉唑和每日两次服用150毫克雷尼替丁在急性十二指肠溃疡短期治疗中的疗效和安全性。121例经内镜证实为活动性十二指肠溃疡的患者（奥美拉唑组61例，雷尼替丁组60例）完成了该研究。奥美拉唑组在2周、4周和6周后的愈合率分别为66%、97%和100%，雷尼替丁组分别为53%、85%和92%。在第4周和第6周时差异具有统计学意义（p<0.05）。两种治疗期间昼夜疼痛均显著减轻，抗酸剂消耗量也减少。两种药物耐受性良好，不良事件少见且程度较轻。根据我们的经验，在十二指肠溃疡的短期治疗中，每日一次服用20毫克奥美拉唑似乎优于每日两次服用150毫克雷尼替丁。
