Eustace K, Clowry J, Kiely C, Murphy G M, Harewood G
Department of Dermatology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland,
Ir J Med Sci. 2015 Mar;184(1):75-6. doi: 10.1007/s11845-014-1136-x. Epub 2014 Jun 10.
Lichen planus is an inflammatory mucocutaneous disorder, often idiopathic. It is postulated that the characteristic skin lesions arise from a T cell mediated autoimmune response against basal keratinocytes. Oral mucosal involvement can occur in up to 70 % of cases of cutaneous disease however, oesphageal involvement is rare.
We report the case of a 60 year old female with ulcerative oesphagitis and concomitant cutaneous lesions suggestive of lichen planus. Multiple immunosuppressant therapies were administered but with little success, except for pulses of oral steroids.
Oesphageal lichen planus is rare, often unrecognised and can be resistant to treatment. However, diagnosis is crucial as malignant transformation of longstanding ulcerative lichen planus may occur.
扁平苔藓是一种炎症性黏膜皮肤疾病，通常为特发性。据推测，其特征性皮肤损害源于针对基底角质形成细胞的T细胞介导的自身免疫反应。口腔黏膜受累在高达70%的皮肤疾病病例中会出现，然而，食管受累罕见。
我们报告了一例60岁女性，患有溃疡性食管炎并伴有提示扁平苔藓的皮肤损害。给予了多种免疫抑制治疗，但除口服类固醇冲击治疗外，效果不佳。
食管扁平苔藓罕见，常未被认识，且可能对治疗有抵抗性。然而，诊断至关重要，因为长期溃疡性扁平苔藓可能会发生恶变。
