Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.
Adv Mater. 2014 Aug 27;26(32):5633-8. doi: 10.1002/adma.201400831. Epub 2014 Jun 10.
An inclusion complex of NaYF4 :Yb(3+) ,Er(3+) upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4 :Yb(3+) ,Er(3+) is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.
在水相条件下，NaYF4：Yb(3+)，Er(3+)上转换纳米粒子与α-环糊精的包含复合物在 980nm 激发时表现出荧光猝灭。这种非辐射弛豫导致了前所未有的光声信号增强。使用活体小鼠的光声断层扫描术证明了覆盖有α-环糊精的 NaYF4：Yb(3+)，Er(3+)的体内定位，显示出其用于光声成像的高能力。
