Bai Youhuang, Dai Xiaozhuan, Harrison Andrew P, Chen Ming
Brief Funct Genomics. 2015 Mar;14(2):91-101. doi: 10.1093/bfgp/elu017. Epub 2014 Jun 9.
A recent highlight of genomics research has been the discovery of many families of transcripts which have function but do not code for proteins. An important group is long noncoding RNAs (lncRNAs), which are typically longer than 200 nt, and whose members originate from thousands of loci across genomes. We review progress in understanding the biogenesis and regulatory mechanisms of lncRNAs. We describe diverse computational and high throughput technologies for identifying and studying lncRNAs. We discuss the current knowledge of functional elements embedded in lncRNAs as well as insights into the lncRNA-based regulatory network in animals. We also describe genome-wide studies of large amount of lncRNAs in plants, as well as knowledge of selected plant lncRNAs with a focus on biotic/abiotic stress-responsive lncRNAs.
基因组学研究最近的一个亮点是发现了许多具有功能但不编码蛋白质的转录本家族。一个重要的类别是长链非编码RNA（lncRNA），其通常长度超过200个核苷酸，并且其成员源自基因组中的数千个基因座。我们综述了在理解lncRNA生物发生和调控机制方面的进展。我们描述了用于鉴定和研究lncRNA的各种计算和高通量技术。我们讨论了lncRNA中嵌入的功能元件的当前知识以及对动物中基于lncRNA的调控网络的见解。我们还描述了植物中大量lncRNA的全基因组研究，以及对选定植物lncRNA的了解，重点是生物/非生物胁迫响应性lncRNA。
