Oribe Naoya, Hirano Yoji, Kanba Shigenobu, Del Re Elisabetta, Seidman Larry, Mesholam-Gately Raquelle, Goldstein Jill M, Shenton Martha, Spencer Kevin M, McCarley Robert W, Niznikiewicz Margaret
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;
Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA;
Schizophr Bull. 2015 Mar;41(2):460-70. doi: 10.1093/schbul/sbu083. Epub 2014 Jun 9.
To understand the underlying dynamic neurophysiological changes over the course of schizophrenia, it is important to study subjects longitudinally from the early stage of the illness. We previously reported that visual P300 was already impaired in patients with first-episode schizophrenia (FESZ). This study demonstrates how the visual P300, as well as earlier components P1, N1, and N200, changed at the 1-year follow-up after their initial measurement.
Visual ERPs were recorded with the same experimental paradigm and acquisition protocol at both time points in FESZ (n = 18) and healthy comparison subjects (n = 24). Participants silently counted infrequent target stimuli ("x") amid standard stimuli ("y") presented on the screen while the 64-channel electroencephalogram was recorded.
FESZ showed smaller visual P300, N200, P1 (trend level) amplitude and delayed P300 and N1 latency at both time points; however, only P300 showed progressive amplitude reduction over the course of the illness at 1-year follow-up. P300 latency did not change over time in either group. FESZ showed significantly reduced Spatial Span total score at both time points, and there was a significant negative correlation between P300 peak amplitude and the Brief Psychiatric Rating Scale positive symptom score at baseline.
These data show progressive P300 amplitude reduction in response to visual stimuli in the early stage of schizophrenia. These visual P300 findings support the concept of progression of schizophrenia, suggesting the usefulness of the visual P300 as a biological marker of progression.
为了解精神分裂症病程中潜在的动态神经生理变化，从疾病早期对受试者进行纵向研究很重要。我们之前报道过首发精神分裂症（FESZ）患者的视觉P300已经受损。本研究展示了视觉P300以及更早的成分P1、N1和N200在首次测量后的1年随访中是如何变化的。
在FESZ患者（n = 18）和健康对照受试者（n = 24）的两个时间点，采用相同的实验范式和采集方案记录视觉事件相关电位（ERP）。参与者在屏幕上呈现的标准刺激（“y”）中默默计数罕见的目标刺激（“x”），同时记录64通道脑电图。
FESZ患者在两个时间点均表现出较小的视觉P300、N200、P1（趋势水平）波幅以及延迟的P300和N1潜伏期；然而，在1年随访中，只有P300在疾病过程中表现出波幅逐渐降低。两组的P300潜伏期均未随时间变化。FESZ患者在两个时间点的空间跨度总分均显著降低，且基线时P300峰值波幅与简明精神病评定量表阳性症状评分之间存在显著负相关。
这些数据表明精神分裂症早期视觉刺激诱发的P300波幅逐渐降低。这些视觉P300的研究结果支持精神分裂症进展的概念，表明视觉P300作为进展的生物学标志物的有用性。
