School of Psychology, Bangor University, Bangor, Gwynedd, UK.
Psychiatry Res. 2012 May 15;197(1-2):140-4. doi: 10.1016/j.psychres.2011.09.030. Epub 2012 Mar 3.
Amplitude reduction of the P300 event-related potential has long been suggested as a marker for schizophrenia. However, recent research has shown that this reduction in the P300 amplitude is not specific to schizophrenia as it can also be observed in related illnesses such as bipolar disorder. Due to this lack of specificity the P300 elicited using traditional oddball paradigms may be a less valuable endophenotypic marker. The current study employed a cognitively demanding three-stimulus oddball paradigm to elicit the P300 to visual target and distracting stimuli. Patients with schizophrenia showed amplitude reductions of P300 components to targets, distractors and frequent stimuli. The P300 in patients with bipolar disorder was not significantly different from either group. The pattern of results may further the understanding of the nature of the impairment in schizophrenia.
P300 事件相关电位的振幅降低一直被认为是精神分裂症的一个标志物。然而，最近的研究表明，这种 P300 振幅的降低并不特异于精神分裂症，因为它也可以在相关疾病如双相情感障碍中观察到。由于这种缺乏特异性，使用传统的Oddball 范式诱发的 P300 可能是一个价值较低的内表型标志物。本研究采用认知要求较高的三刺激Oddball 范式来诱发视觉靶刺激和干扰刺激的 P300。精神分裂症患者的 P300 靶刺激、干扰刺激和高频刺激成分的振幅均降低。双相情感障碍患者的 P300 与任何一组均无显著差异。这些结果的模式可能进一步加深对精神分裂症损害性质的理解。
