Sala P, Tonutti E, Giuliano M, Fuccaro V, Bramezza M
Instituto di Chimica Clinica, Ospedale Generale, S. Maria della Misericordia, Udine.
Boll Ist Sieroter Milan. 1989;68(3):224-7.
During a five years survey of unselected serum protein electrophoreses in a general hospital, 2347 sera (0.95%) were found to be positive for one or more monoclonal immunoglobulins. Class and type distribution of monoclonal immunoglobulins (characterized by means of immunofixation electrophoresis) mostly corresponded with the literature data. Nevertheless, higher incidence and lower mean age at detection were observed for IgG monoclonal components. This finding is probably related to the discovery of a large number of micro-monoclonal immunoglobulins with no association with B-lymphoproliferative disorders, mostly belonging to the IgG class and affecting younger people. The need is stressed for a widespread standardization of the techniques employed for detection and characterization of monoclonal immunoglobulins, in order to obtain more comparable results.
在一家综合医院对未经筛选的血清蛋白电泳进行的为期五年的调查中，发现2347份血清（0.95%）有一种或多种单克隆免疫球蛋白呈阳性。单克隆免疫球蛋白的类别和类型分布（通过免疫固定电泳确定）大多与文献数据相符。然而，观察到IgG单克隆成分的发病率较高且检测时的平均年龄较低。这一发现可能与发现大量与B淋巴细胞增殖性疾病无关的微小单克隆免疫球蛋白有关，这些球蛋白大多属于IgG类且影响年轻人。强调了对用于检测和鉴定单克隆免疫球蛋白的技术进行广泛标准化的必要性，以便获得更具可比性的结果。
