Na Gun Hyung, Kim Dong Goo, Han Jae Hyun, Kim Eun Young, Lee Soo Ho, Hong Tae Ho, You Young Kyoung
Gun Hyung Na, Dong Goo Kim, Jae hyun Han, Eun Young Kim, Soo Ho Lee, Tae Ho Hong, Young Kyoung You, Department of Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 137-701, South Korea.
World J Gastroenterol. 2014 Jun 7;20(21):6594-601. doi: 10.3748/wjg.v20.i21.6594.
To investigate that inflammatory markers can predict accurately the prognosis of hepatocelluar carcinoma (HCC) patients in living-donor liver transplantation (LDLT).
From October 2000 to November 2011, 224 patients who underwent living donor liver transplantation for HCC at our institution were enrolled in this study. We analyzed disease-free survival (DFS) and overall survival (OS) after LT in patients with HCC and designed a new score model using pretransplant neutrophil-lymphocyte ratio (NLR) and C-reactive protein (CRP).
The DFS and OS in patients with an NLR level ≥ 6.0 or CRP level ≥ 1.0 were significantly worse than those of patients with an NLR level < 6.0 or CRP level < 1.0 (P = 0.049, P = 0.003 for NLR and P = 0.010, P < 0.001 for CRP, respectively). Using a new score model using the pretransplant NLR and CRP, we can differentiate HCC patients beyond the Milan criteria with a good prognosis from those with a poor prognosis.
Combined with the Milan criteria, new score model using NLR and CRP represent new selection criteria for LDLT candidates with HCC, especially beyond the Milan criteria.
探讨炎症标志物能否准确预测活体肝移植（LDLT）中肝细胞癌（HCC）患者的预后。
2000年10月至2011年11月，本研究纳入了在我院接受活体肝移植治疗HCC的224例患者。我们分析了HCC患者肝移植后的无病生存期（DFS）和总生存期（OS），并使用移植前中性粒细胞与淋巴细胞比值（NLR）和C反应蛋白（CRP）设计了一种新的评分模型。
NLR水平≥6.0或CRP水平≥1.0的患者的DFS和OS显著低于NLR水平<6.0或CRP水平<1.0的患者（NLR分别为P = 0.049，P = 0.003；CRP分别为P = 0.010，P < 0.001）。使用移植前NLR和CRP的新评分模型，我们可以区分米兰标准以外预后良好的HCC患者和预后不良的患者。
结合米兰标准，使用NLR和CRP的新评分模型代表了HCC患者LDLT候选者的新选择标准，特别是对于米兰标准以外的患者。
