Schurizek B A, Kraglund K, Andreasen F, Vinter-Jensen L, Juhl B
Department of Anaesthesiology and Surgical Gastroenterology, University Hospital of Aarhus, Denmark.
Aliment Pharmacol Ther. 1989 Feb;3(1):93-101. doi: 10.1111/j.1365-2036.1989.tb00194.x.
The influence of paracetamol on antroduodenal motility and gastric pH was studied in 11 healthy subjects and the relationship between gastroduodenal motility and gastric emptying rate time, tmax, to peak concentration of serum paracetamol, Cmax, was evaluated. The incidence of antral phase III activity and the duration of phase III was diminished with paracetamol (P less than 0.05). The other motility parameters assessed were unchanged. Three patterns of motility and absorption were observed. One group (n = 5) were fast absorbers with a tmax of 1 h and a motility pattern characterized by antral activity, a high motility index and a short duration of phase II (33-60 min); the phase IIIs were complete except in one case. The second group (n = 4) had tmax at 1.5 h and their phase II motility was characterized by a longer duration (80-133 min) (P less than 0.05), by antral activity, and by a high motility index; their phase IIIs were all incomplete. The last group (n = 2) were slow absorbers: Cmax was not reached in the investigation period, no antral contractions were seen, and the motility index was low. The area under the serum-concentration curve of paracetamol differed between the groups at 90 and 180 min (P less than 0.01).
在11名健康受试者中研究了对乙酰氨基酚对胃十二指肠运动及胃pH值的影响，并评估了胃十二指肠运动与胃排空速率时间（tmax）以及血清对乙酰氨基酚峰值浓度（Cmax）之间的关系。对乙酰氨基酚可使胃窦Ⅲ期活动的发生率及Ⅲ期持续时间降低（P<0.05）。所评估的其他运动参数未发生改变。观察到三种运动及吸收模式。一组（n = 5）为快速吸收者，tmax为1小时，其运动模式的特征为胃窦活动、高运动指数及Ⅱ期持续时间短（33 - 60分钟）；除1例情况外，Ⅲ期均完整。第二组（n = 4）的tmax为1.5小时，其Ⅱ期运动的特征为持续时间更长（80 - 133分钟）（P<0.05）、有胃窦活动及高运动指数；其Ⅲ期均不完整。最后一组（n = 2）为缓慢吸收者：在研究期间未达到Cmax，未观察到胃窦收缩，且运动指数较低。对乙酰氨基酚血清浓度曲线下面积在各时间点（90分钟和180分钟）的组间存在差异（P<0.01）。
