氟烷全身麻醉对人体胃十二指肠运动、pH值及胃排空率的影响。

Effects of general anaesthesia with halothane on antroduodenal motility, pH and gastric emptying rate in man.

作者信息

Schurizek B A, Willacy L H, Kraglund K, Andreasen F, Juhl B

机构信息

Department of Anaesthesiology and Surgical Gastroenterology, University Hospital of Aarhus, Denmark.

出版信息

Br J Anaesth. 1989 Feb;62(2):129-37. doi: 10.1093/bja/62.2.129.

DOI:10.1093/bja/62.2.129

PMID:2923764

Abstract

Antroduodenal motility, pH and gastric emptying rate were measured in 11 patients undergoing orthopaedic or plastic surgery with general anaesthesia. Motility was measured by manometry and gastric emptying rate by the rate of paracetamol absorption. During anaesthesia, gastric emptying was delayed in eight patients. General anaesthesia with halothane reduced the duration of the interdigestive motility complex (P less than 0.01), mainly by a shortening of phase II (P less than 0.01) which correlated with the inhaled concentrations of halothane (P less than 0.01). Anaesthesia impeded the occurrence of antral contractions during phase II (P less than 0.01); the frequency of contractions was unchanged during anaesthesia, but decreased during the recovery period (P less than 0.01). The amplitudes of antral contractions diminished with anaesthesia (P less than 0.01), but increased after operation. The frequency of contractions in the duodenum was unchanged during phase II and reduced during phase III (P less than 0.01). Gastric pH increased during and after operation (P less than 0.01). General anaesthesia with halothane affects gastroduodenal motility especially during phase II, increases gastric pH and delays gastric emptying rate.

摘要

对11例接受全身麻醉的骨科或整形外科手术患者的十二指肠运动、pH值和胃排空率进行了测量。通过测压法测量运动，通过对乙酰氨基酚吸收速率测量胃排空率。麻醉期间，8例患者胃排空延迟。氟烷全身麻醉缩短了消化间期移行性复合运动的持续时间（P<0.01），主要是通过缩短Ⅱ期（P<0.01），这与氟烷吸入浓度相关（P<0.01）。麻醉妨碍了Ⅱ期胃窦收缩的发生（P<0.01）；麻醉期间收缩频率未改变，但恢复期降低（P<0.01）。胃窦收缩幅度随麻醉而减小（P<0.01），但术后增加。十二指肠收缩频率在Ⅱ期未改变，在Ⅲ期降低（P<0.01）。手术期间及术后胃pH值升高（P<0.01）。氟烷全身麻醉尤其在Ⅱ期影响胃十二指肠运动，增加胃pH值并延迟胃排空率。