Knight Jennifer M, Moynihan Jan A, Lyness Jeffrey M, Xia Yinglin, Tu Xin, Messing Susan, Hunter Bryan C, Huang Li-Shan, Obi Rosemary O, Gaisser D'Arcy, Liesveld Jane L, Sahler Olle Jane Z
University of Rochester Medical Center, Department of Psychiatry, the Rochester Center for Mind-Body Research, Rochester, New York, United States of America.
University of Rochester Medical Center, Department of Biostatistics and Computational Biology, Rochester, New York, United States of America.
PLoS One. 2014 Jun 10;9(6):e99778. doi: 10.1371/journal.pone.0099778. eCollection 2014.
Multiple psychosocial factors appear to affect cancer progression in various populations; however, research investigating the relationship between psychosocial factors and outcomes following hematopoietic stem cell transplantation (HCT) is scarce. Subject to adverse immunological and psychological conditions, HCT patients may be especially vulnerable to psychosomatic health sequelae; therefore, we studied whether optimism and anxiety influence the pertinent clinical outcome of days to neutrophil engraftment (DTE).
54 adults undergoing either autologous or allogeneic HCT completed self-report questionnaires measuring optimism and anxiety. We assessed the association between these psychosocial variables and DTE.
Greater optimism and less anxiety were associated with the favorable outcome of fewer DTE in autologous HCT recipients, though this relationship was no longer significant when reducing the sample size to only subjects who filled out their baseline survey by the time of engraftment.
Our findings are suggestive that optimism and anxiety may be associated with time to neutrophil recovery in autologous, but not allogeneic, adult HCT recipients. Further investigation in larger, more homogeneous subjects with consistent baseline sampling is warranted.
多种社会心理因素似乎会影响不同人群的癌症进展；然而，关于社会心理因素与造血干细胞移植（HCT）后结局之间关系的研究却很匮乏。由于免疫和心理状况不佳，HCT患者可能特别容易出现身心方面的健康后遗症；因此，我们研究了乐观情绪和焦虑情绪是否会影响中性粒细胞植入天数（DTE）这一相关临床结局。
54名接受自体或异基因HCT的成年人完成了测量乐观情绪和焦虑情绪的自我报告问卷。我们评估了这些社会心理变量与DTE之间的关联。
在自体HCT受者中，更乐观和更少焦虑与DTE天数较少这一良好结局相关，不过，当将样本量减少到仅移植时填写了基线调查的受试者时，这种关系不再显著。
我们的研究结果表明，乐观情绪和焦虑情绪可能与自体（而非异体）成年HCT受者中性粒细胞恢复的时间有关。有必要在更大规模、更同质且基线采样一致的受试者中进行进一步研究。
