Caterina Michael J
Departments of Neurosurgery, Biological Chemistry, and Neuroscience, Neurosurgery Pain Research Institute, Center for Sensory Biology, Johns Hopkins School of Medicine , 725 N. Wolfe St., Baltimore, Maryland 21205, United States.
ACS Chem Neurosci. 2014 Nov 19;5(11):1107-16. doi: 10.1021/cn5000919. Epub 2014 Jun 17.
In the skin, cannabinoid lipids, whether of endogenous or exogenous origin, are capable of regulating numerous sensory, homeostatic, and inflammatory events. Although many of these effects are mediated by metabotropic cannabinoid receptors, a growing body of evidence has revealed that multiple members of the transient receptor potential (TRP) ion channel family can act as "ionotropic cannabinoid receptors". Furthermore, many of these same TRP channels are intimately involved in cutaneous processes that include the initiation of pain, temperature, and itch perception, the maintenance of epidermal homeostasis, the regulation of hair follicles and sebaceous glands, and the modulation of dermatitis. Ionotropic cannabinoid receptors therefore represent potentially attractive targets for the therapeutic use of cannabinoids to treat sensory and dermatological diseases. Furthermore, the interactions between neurons and other cell types that are mediated by cutaneous ionotropic cannabinoid receptors are likely to be recapitulated during physiological and pathophysiological processes in the central nervous system and elsewhere, making the skin an ideal setting in which to dissect general complexities of cannabinoid signaling.
在皮肤中，大麻素脂质，无论其来源是内源性还是外源性，都能够调节众多的感觉、稳态和炎症反应。尽管其中许多作用是由代谢型大麻素受体介导的，但越来越多的证据表明，瞬时受体电位（TRP）离子通道家族的多个成员可作为“离子型大麻素受体”。此外，许多相同的TRP通道密切参与皮肤相关过程，包括疼痛、温度和瘙痒感知的起始、表皮稳态的维持、毛囊和皮脂腺的调节以及皮炎的调控。因此，离子型大麻素受体代表了大麻素用于治疗感觉和皮肤病的潜在有吸引力的靶点。此外，由皮肤离子型大麻素受体介导的神经元与其他细胞类型之间的相互作用，很可能在中枢神经系统及其他部位的生理和病理生理过程中重现，这使得皮肤成为剖析大麻素信号传导一般复杂性的理想环境。
