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Targeting the endogenous cannabinoid system to treat neuropathic pain.

作者信息

Lau Benjamin K, Vaughan Christopher W

机构信息

Pain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, University of Sydney Sydney, NSW, Australia.

出版信息

Front Pharmacol. 2014 Mar 3;5:28. doi: 10.3389/fphar.2014.00028. eCollection 2014.

DOI:10.3389/fphar.2014.00028
PMID:24624084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3939704/
Abstract
摘要

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本文引用的文献

1
Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications.提高内源性大麻素水平：药理学策略和潜在的治疗应用。
Proc Nutr Soc. 2014 Feb;73(1):96-105. doi: 10.1017/S0029665113003649. Epub 2013 Oct 18.
2
In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects.体内鉴定高度选择性单酰基甘油脂肪酶抑制剂 KML29：无大麻样副作用的镇痛活性。
Br J Pharmacol. 2014 Mar;171(6):1392-407. doi: 10.1111/bph.12298.
3
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.重复给予低剂量的单酰基甘油脂肪酶抑制剂 JZL184 可保留大麻素受体 1 介导的镇痛和胃保护作用。
J Pharmacol Exp Ther. 2013 Jun;345(3):492-501. doi: 10.1124/jpet.112.201426. Epub 2013 Feb 14.
4
Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice.双重抑制内源性大麻素代谢酶可增强吗啡依赖小鼠的戒断效应。
Neuropsychopharmacology. 2013 May;38(6):1039-49. doi: 10.1038/npp.2012.269. Epub 2013 Jan 3.
5
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment.化疗诱导的周围神经病变后内源性大麻素的变化：与顺铂治疗后参考镇痛药相比，靶向脂肪酸酰胺水解酶和单酰基甘油脂肪酶的内源性大麻素失活抑制剂的作用。
Pharmacol Res. 2013 Jan;67(1):94-109. doi: 10.1016/j.phrs.2012.10.013. Epub 2012 Nov 2.
6
Why do cannabinoid receptors have more than one endogenous ligand?大麻素受体为何有不止一种内源性配体？
Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3216-28. doi: 10.1098/rstb.2011.0382.
7
"Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control.“内源性大麻素失活”的冗余性：疼痛控制的新挑战和新机遇。
ACS Chem Neurosci. 2012 May 16;3(5):356-63. doi: 10.1021/cn300015x. Epub 2012 Feb 27.
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Pain. 2012 Sep;153(9):1785-1786. doi: 10.1016/j.pain.2012.06.016. Epub 2012 Jul 10.
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Pain. 2012 Sep;153(9):1837-1846. doi: 10.1016/j.pain.2012.04.020. Epub 2012 Jun 21.
10
The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models.新型可逆脂肪酸酰胺水解酶抑制剂 ST4070 可增加大脑中的内源性大麻素水平，并在不同的动物模型中缓解神经病理性疼痛。
J Pharmacol Exp Ther. 2012 Jul;342(1):188-95. doi: 10.1124/jpet.111.191403. Epub 2012 Apr 18.