Laboratory of Asymmetric Catalysis and Synthesis, EPFL SB ISIC LCSA, BCH 4305, 1015 Lausanne (Switzerland) http://isic.epfl.ch/lcsa.
Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7896-9. doi: 10.1002/anie.201404895. Epub 2014 Jun 10.
Directed Cp*Rh(III)-catalyzed carbon-hydrogen (C-H) bond functionalizations have evolved as a powerful strategy for the construction of heterocycles. Despite their high value, the development of related asymmetric reactions is largely lagging behind due to a limited availability of robust and tunable chiral cyclopentadienyl ligands. Rhodium complexes comprising a chiral Cp ligand with an atropchiral biaryl backbone enables an asymmetric synthesis of isoindolones from arylhydroxamates and weakly alkyl donor/acceptor diazo derivatives as one-carbon component under mild conditions. The complex guides the substrates with a high double facial selectivity yielding the chiral isoindolones in good yields and excellent enantioselectivities.
导向的 Cp*Rh(III)-催化的碳-氢键（C-H）键功能化已经发展成为构建杂环的一种强大策略。尽管它们具有很高的价值，但由于缺乏强大且可调谐的手性环戊二烯基配体，相关的不对称反应的发展在很大程度上滞后了。铑配合物包含一个具有轴手性联芳骨架的手性 Cp 配体，能够在温和条件下从芳基羟胺和弱的烷基给体/受体重氮衍生物作为一碳组分不对称合成异吲哚酮。该配合物以高双面选择性引导底物，以良好的收率和优异的对映选择性得到手性异吲哚酮。
