Uchida Ryuji, Yokota Sayaka, Matsuda Daisuke, Matsumoto Atsuko, Iwamoto Susumu, Onodera Hideyuki, Takahashi Yoko, Tomoda Hiroshi
Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
J Antibiot (Tokyo). 2014 Nov;67(11):777-81. doi: 10.1038/ja.2014.62. Epub 2014 Jun 11.
A small molecule named habiterpenol produced by actinomycete Phytohabitans suffuscus 3787_5 was found to abrogate bleomycin-induced G2 arrest in Jurkat cells. Habiterpenol showed no cytotoxic effect on Jurkat cells even at 273 μM; however, the compound inhibited bleomycin-induced G2 arrest in Jurkat cells with an IC50 value of 3.55 μM, while it showed no effect on colchicine-induced M arrest even at 273 μM. These results indicated that habiterpenol selectively abrogated bleomycin-induced G2 arrest in Jurkat cells.
人们发现，放线菌植物栖居菌3787_5产生的一种名为habiterpenol的小分子可消除博来霉素诱导的Jurkat细胞G2期阻滞。即使在273μM浓度下，habiterpenol对Jurkat细胞也没有细胞毒性作用；然而，该化合物抑制博来霉素诱导的Jurkat细胞G2期阻滞的IC50值为3.55μM，而即使在273μM浓度下，它对秋水仙碱诱导的M期阻滞也没有影响。这些结果表明，habiterpenol可选择性消除博来霉素诱导的Jurkat细胞G2期阻滞。
