由暗褐栖植物菌3787_5产生的新型博来霉素诱导的Jurkat细胞G2期阻滞抑制剂杂萜醇的结构解析。

Structure elucidation of meroterpenoid habiterpenol, a novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, produced by Phytohabitans suffuscus 3787_5.

作者信息

Uchida Ryuji, Yokota Sayaka, Tomoda Hiroshi

机构信息

Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 2014 Nov;67(11):783-6. doi: 10.1038/ja.2014.71. Epub 2014 Jun 11.

DOI:10.1038/ja.2014.71

PMID:24916894

Abstract

A novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, habiterpenol (1), was isolated from the culture broth of Phytohabitans suffuscus 3787_5. The planar structure of 1 was elucidated by spectroscopic study (1D and 2D NMR, MS, UV and IR), and the relative stereochemistry was elucidated by ROESY experiments. Compound 1 belongs to a pentacyclic meroterpenoid having a labdan-type diterpene connecting to an indane moiety.

摘要

从深褐栖植物3787_5的培养液中分离出一种新型的博来霉素诱导Jurkat细胞G2期阻滞的消除剂——哈比萜醇（1）。通过光谱研究（一维和二维核磁共振、质谱、紫外和红外）阐明了1的平面结构，并通过旋转 Overhauser 效应光谱（ROESY）实验阐明了其相对立体化学。化合物1属于一种五环杂萜类化合物，具有连接到茚满部分的赖百当型二萜。