Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland.
Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland ; Department of Sport Education, Academy of Physical Education and Sport, Gdańsk, Poland.
Biol Sport. 2014 Mar;31(1):21-5. doi: 10.5604/20831862.1083275. Epub 2014 Jan 22.
The GNB3 gene encodes the beta 3 subunit of heterotrimeric G-proteins that are key components of intracellular signal transduction between G protein-coupled receptors (GPCR) and intracellular effectors and might be considered as a potential candidate gene for physical performance.
The aim of this study was to compare frequency distribution of the common C to T polymorphism at position 825 (C825T) of the GNB3 gene between athletes and nonathletic controls of the Polish population as well as to compare the genotype distribution and allele frequency of C825T variants within a group of athletes, i.e. between athletes of sports of different metabolic demands and competitive levels.
The study was performed in a group of 223 Polish athletes of the highest nationally competitive standard (123 endurance-oriented athletes and 100 strength/ power athletes). Control samples were prepared from 354 unrelated, sedentary volunteers.
The χ(2) test revealed no statistical differences between the endurance-oriented athletes and the control group or between sprint/strength athletes and the control group across the GNB3 825C/T genotypes. There were no male-female genotype or allele frequency differences in controls or in either strength/power or endurance-oriented athletes. No statistically significant differences in either allele frequencies or genotype distribution were noted between the top-elite, elite or sub-elite of endurance-oriented and strength/power athletes and the control group.
No association between elite status of Polish athletes and the GNB3 C825T polymorphic site has been found.
GNB3 基因编码异三聚体 G 蛋白的 β3 亚基，G 蛋白是 G 蛋白偶联受体（GPCR）和细胞内效应器之间细胞内信号转导的关键组成部分，可被视为身体表现的潜在候选基因。
本研究旨在比较波兰人群中运动员和非运动员对照之间 GNB3 基因常见 C 到 T 多态性（C825T）的频率分布，以及比较不同代谢需求和竞技水平的运动员群体内 C825T 变体的基因型分布和等位基因频率。
该研究在 223 名波兰最高国家级竞技标准的运动员（123 名耐力型运动员和 100 名力量/力量型运动员）中进行。对照组由 354 名无亲缘关系、久坐不动的志愿者组成。
卡方检验显示，在 GNB3 825C/T 基因型方面，耐力型运动员与对照组或短跑/力量型运动员与对照组之间没有统计学差异。对照组或力量/力量型或耐力型运动员中，男性和女性的基因型或等位基因频率没有差异。在耐力型和力量/力量型运动员的顶尖精英、精英或次精英与对照组之间，等位基因频率或基因型分布均无统计学差异。
未发现波兰运动员的精英地位与 GNB3 C825T 多态性位点之间存在关联。
