Laboratory of Biochemistry, Rabta Hospital, Tunisia ; Research Laboratory "Sport Performance Optimization", National Center for Medicine and Sciences of Sports, Tunisia.
Laboratory of Biochemistry, Rabta Hospital, Tunisia.
Biol Sport. 2014 Mar;31(1):49-54. doi: 10.5604/20831862.1086732. Epub 2014 Jan 22.
Creatine plays a key role in muscle function and its evaluation is important in athletes. In this study, urinary creatine concentration was measured in order to highlight its possible significance in monitoring sprinters. The study included 51 sprinters and 25 age- and sex-matched untrained subjects as a control group. Body composition was measured and dietary intake estimated. Urine samples were collected before and after standardized physical exercise. Creatine was assessed by gas chromatography mass spectrometry. Basal urinary creatine (UC) was significantly lower in sprinters than controls (34±30 vs. 74±3 µmol/mmol creatinine, p < 0.05). UC was inversely correlated with body mass (r = -0.34, p < 0.01) and lean mass (r = -0.30, p < 0.05), and positively correlated with fat mass (r = 0.32, p < 0.05). After acute exercise, urinary creatine significantly decreased in both athletes and controls. UC is low in sprinters at rest and further decreases after exercise, most likely due to a high uptake and use of creatine by muscles, as muscle mass and physical activity are supposed to be greater in athletes than untrained subjects. Further studies are needed to test the value of urinary creatine as a non-invasive marker of physical condition and as a parameter for managing Cr supplementation in athletes.
肌酸在肌肉功能中起着关键作用，其评估对运动员很重要。在这项研究中，测量了尿肌酸浓度，以突出其在监测短跑运动员中的可能意义。该研究包括 51 名短跑运动员和 25 名年龄和性别匹配的未经训练的受试者作为对照组。测量了身体成分并估计了饮食摄入量。收集了标准化体育锻炼前后的尿液样本。通过气相色谱-质谱法评估肌酸。与对照组相比，短跑运动员的基础尿肌酸（UC）明显较低（34±30 与 74±3 μmol/mmol 肌酐，p<0.05）。UC 与体重（r=-0.34，p<0.01）和瘦体重（r=-0.30，p<0.05）呈负相关，与脂肪量（r=0.32，p<0.05）呈正相关。急性运动后，运动员和对照组的尿肌酸均显著下降。休息时短跑运动员的 UC 较低，运动后进一步下降，最有可能是由于肌肉大量摄取和使用肌酸，因为肌肉质量和体育活动应高于未经训练的受试者。需要进一步研究以测试尿肌酸作为身体状况的非侵入性标志物和作为运动员 Cr 补充管理参数的价值。
