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Activation of microglia bolsters synapse formation.

作者信息

Cristovão Gonçalo, Pinto Maria J, Cunha Rodrigo A, Almeida Ramiro D, Gomes Catarina A

机构信息

CNC-Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal ; PhD Programme in Experimental Biology and Biomedicine (PDBEB), Center for Neuroscience and Cell Biology, University of Coimbra Coimbra, Portugal.

出版信息

Front Cell Neurosci. 2014 Jun 2;8:153. doi: 10.3389/fncel.2014.00153. eCollection 2014.

DOI:10.3389/fncel.2014.00153
PMID:24917790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4040490/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c52/4040490/45b83d940e15/fncel-08-00153-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c52/4040490/45b83d940e15/fncel-08-00153-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c52/4040490/45b83d940e15/fncel-08-00153-g0001.jpg

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Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase.小胶质细胞 CR3 的激活通过 NADPH 氧化酶触发海马体的长期突触抑制。
Neuron. 2014 Apr 2;82(1):195-207. doi: 10.1016/j.neuron.2014.01.043. Epub 2014 Mar 13.
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Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.
突触形成刺激轴突中的蛋白酶体介导的核糖体减少。
Cell Rep. 2019 Jul 23;28(4):864-876.e6. doi: 10.1016/j.celrep.2019.06.080.
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Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF.间质干细胞分泌组诱导的轴突生长是由 BDNF 介导的。
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Microglia: Housekeeper of the Central Nervous System.小胶质细胞：中枢神经系统的管家。
Cell Mol Neurobiol. 2018 Jan;38(1):53-71. doi: 10.1007/s10571-017-0504-2. Epub 2017 May 22.
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Adenosine A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety.腺苷 A 受体对小胶质细胞形态重塑的调节——生理性别差异和慢性焦虑模型中的性别差异。
Mol Psychiatry. 2017 Jul;22(7):1035-1043. doi: 10.1038/mp.2016.173. Epub 2016 Oct 11.
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Visualizing K48 Ubiquitination during Presynaptic Formation By Ubiquitination-Induced Fluorescence Complementation (UiFC).通过泛素化诱导荧光互补（UiFC）在突触前形成过程中可视化K48泛素化
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