Sakimoto Yuya, Sakata Shogo
Department of Systems Neuroscience, Graduate School of Medicine, Yamaguchi University Yamaguchi, Japan.
Department of Behavioral Sciences, Graduate School of Integrated Arts and Sciences, Hiroshima University Hiroshima, Japan.
Front Behav Neurosci. 2014 Jun 3;8:159. doi: 10.3389/fnbeh.2014.00159. eCollection 2014.
It was showed that solving a simple discrimination task (A+, B-) and a simultaneous feature-negative (FN) task (A+, AB-) used the hippocampal-independent strategy. Recently, we showed that the number of sessions required for a rat to completely learn a task differed between the FN and simple discrimination tasks, and there was a difference in hippocampal theta activity between these tasks. These results suggested that solving the FN task relied on a different strategy than the simple discrimination task. In this study, we provided supportive evidence that solving the FN and simple discrimination tasks involved different strategies by examining changes in performance and hippocampal theta activity in the FN task after transfer from the simple discrimination task (A+, B- → A+, AB-). The results of this study showed that performance on the FN task was impaired and there was a difference in hippocampal theta activity between the simple discrimination task and FN task. Thus, we concluded that solving the FN task uses a different strategy than the simple discrimination task.
结果表明，解决简单辨别任务（A+，B-）和同时性特征负性（FN）任务（A+，AB-）采用的是不依赖海马体的策略。最近，我们发现大鼠完全学会一项任务所需的实验次数在FN任务和简单辨别任务之间存在差异，并且这些任务之间海马体θ活动也存在差异。这些结果表明，解决FN任务所依赖的策略与简单辨别任务不同。在本研究中，我们通过检查从简单辨别任务（A+，B- → A+，AB-）转换后FN任务中的表现变化和海马体θ活动，提供了支持性证据，证明解决FN任务和简单辨别任务涉及不同的策略。本研究结果表明，FN任务的表现受到损害，并且简单辨别任务和FN任务之间海马体θ活动存在差异。因此，我们得出结论，解决FN任务所使用的策略与简单辨别任务不同。
