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一名老年男性的暴发性酒渣鼻伴面部以外病变:小剂量抗菌多西环素治疗成功

Rosacea fulminans with extrafacial lesions in an elderly man: successful treatment with subantimicrobial-dose doxycycline.

作者信息

Smith Lauren A, Meehan Shane A, Cohen David E

出版信息

J Drugs Dermatol. 2014 Jun;13(6):763-5.

Abstract

Rosacea fulminans, previously known as pyoderma faciale, is a rare disease occurring almost exclusively in young women characterized by the sudden eruption of coalescing papules and pustules, and large cystic nodules limited to the face. Patients generally respond well to standard therapy consisting of systemic isotretinoin in combination with topical and systemic corticosteroids. Lesions usually resolve with minimal scarring with appropriate management. We describe an elderly male patient with extrafacial rosacea fulminans successfully treated with daily subantimicrobial (40mg) dose doxycycline (SDD). To our knowledge, this is the first report of rosacea fulminans with extrafacial lesions in an elderly male. We suggest that SDD may be a safe and effective alternative, particularly for those unable to tolerate standard therapy.

摘要

暴发性酒渣鼻,以前称为面部脓皮病,是一种几乎仅发生于年轻女性的罕见疾病,其特征为突然出现融合性丘疹、脓疱以及局限于面部的大囊性结节。患者通常对由系统性异维A酸联合局部及系统性皮质类固醇组成的标准治疗反应良好。通过适当管理,皮损通常在瘢痕形成最少的情况下消退。我们描述了一名患有面部外暴发性酒渣鼻的老年男性患者,该患者通过每日服用亚抗菌剂量(40mg)的多西环素(SDD)成功治愈。据我们所知,这是关于老年男性面部外皮损暴发性酒渣鼻的首例报告。我们认为SDD可能是一种安全有效的替代疗法,尤其适用于那些无法耐受标准治疗的患者。

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