Weary Taylor E, Mehta Kavi P M, Goldberg Tony L
Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, WI, USA.
Department of Comparative Biosciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, WI, USA.
Access Microbiol. 2024 Aug 20;6(8). doi: 10.1099/acmi.0.000866.v3. eCollection 2024.
Papillomaviruses (PVs) are double-stranded, circular, epitheliotropic DNA viruses causing benign warts (papillomas) or inducing dysplasia that can progress to cancer. Although they have been identified in all vertebrate taxa, most classified types are human PVs (HPVs); relatively little is known about PVs in other species. Here we characterize a novel type, PtepPV1, from a nasal swab of a wild red colobus () in Kibale National Park, Uganda. The virus has a genome of 6576 bases, encoding the seven canonical early (E) ORFs (E6, E7, E1, E2, E4, E1^E4 and E8^E2) and two late (L) ORFs (L1 and L2) of the gammapapillomaviruses, and is 81.0% similar to HPV-mSK_118, detected in a cutaneous wart from an immunocompromised human patient, in the L1 gene at the amino acid level. Alphapapillomaviruses (genus ) cause anogenital carcinomas such as cervical cancer and have been described previously in several nonhuman primates. However, the first gammapapillomavirus (genus ), which cause transient cutaneous infections, was not described until 2019 in a healthy rhesus macaque () genital swab. The new virus from red colobus, PtepPV1, has many genomic features encoded by high-risk oncogenic PVs, such as the E7 gene LXSXE and CXXC motifs, suggesting potential for pRb and zinc-finger binding, respectively. To our knowledge, PtepPV1 is also the first reported nonhuman primate PV found in the nasal cavity. PtepPV1 expands the known host range, geographical distribution, tissue tropism and biological characteristics of nonhuman primate PVs.
乳头瘤病毒（PVs）是双链环状嗜上皮性DNA病毒，可引起良性疣（乳头瘤）或诱发发育异常，进而发展为癌症。尽管在所有脊椎动物类群中都已发现它们，但大多数分类类型是人类乳头瘤病毒（HPVs）；人们对其他物种中的PVs了解相对较少。在这里，我们从乌干达基巴莱国家公园一只野生红疣猴（）的鼻拭子中鉴定出一种新型病毒，即PtepPV1。该病毒基因组有6576个碱基，编码γ乳头瘤病毒的七个典型早期（E）开放阅读框（E6、E7、E1、E2、E4、E1^E4和E8^E2）和两个晚期（L）开放阅读框（L1和L2），在氨基酸水平上，其L1基因与在一名免疫功能低下人类患者的皮肤疣中检测到的HPV-mSK_118相似度为81.0%。α乳头瘤病毒（属）可引起肛门生殖器癌，如宫颈癌，此前已在几种非人类灵长类动物中被描述。然而，第一种γ乳头瘤病毒（属），可引起短暂的皮肤感染，直到2019年才在一只健康恒河猴（）的生殖器拭子中被描述。来自红疣猴的新病毒PtepPV1具有许多由高危致癌PVs编码的基因组特征，如E7基因的LXSXE和CXXC基序，分别提示与pRb和锌指结合的潜力。据我们所知,PtepPV1也是首次报道的在鼻腔中发现的非人类灵长类动物PV。PtepPV1扩展了已知的非人类灵长类动物PV的宿主范围、地理分布、组织嗜性和生物学特性。
