通过 Ru(II)-Pheox 催化的丙二烯的不对称分子内和分子间环丙烷化反应，高区域和立体选择性合成亚烷基环丙烷。
Highly regio- and stereoselective synthesis of alkylidenecyclopropanes via Ru(II)-Pheox catalyzed asymmetric inter- and intramolecular cyclopropanation of allenes.
机构信息
Department of Environmental, Life Sciences, Toyohashi University of Technology , 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Japan.
出版信息
Org Lett. 2014 Jun 20;16(12):3408-11. doi: 10.1021/ol5014944. Epub 2014 Jun 11.
PMID:24918864
Abstract
An efficient protocol for the synthesis of optically active alkylidenecyclopropanes (ACPs) via the Ru(II)-Pheox catalyzed asymmetric cyclopropanation of allenes has been established. This catalytic system proceeded with high regioselectivity to give the ACP products in high yield with high diastereoselectivity (up to 99/1) and enantioselectivity (up to 99% ee).
摘要
建立了一种通过 Ru(II)-Pheox 催化的丙二烯不对称环丙烷化反应高效合成手性亚烷基环丙烷（ACPs）的方法。该催化体系具有高区域选择性，以高产率和高非对映选择性（高达 99/1）和对映选择性（高达 99%ee）得到 ACP 产物。
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