Mbuagbaw Lawrence, Forlemu-Kamwa Doris, Chu Angela, Thabane Lehana, Dillenberg Rejane
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare, Hamilton, Ontario, Canada Centre for Development of Best Practices in Health, Yaoundé Central Hospital, Yaoundé, Cameroon.
Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
BMJ Open. 2014 Jun 11;4(6):e005123. doi: 10.1136/bmjopen-2014-005123.
Dextro-transposition of the great arteries (d-TGA) is a life-threatening congenital health defect that requires rapid surgery. The most widely used approach is the arterial switch operation (ASO) developed by Jatene in the 1970s. The first set of children who received this intervention are now adults. The objective of this scoping review of the literature was to document the short-term (less than 1 year), medium-term (1-20 years) and long-term (more than 20 years) outcomes in children who underwent the ASO. Our primary income is survival, but we will explore other secondary surgical, cardiovascular, reproductive and quality-of-life outcomes.
Using a systematic scoping review approach, we will conduct a systematic search of the published literature for experimental and observational studies published on children who received the ASO intervention for classic d-TGA. We will search MEDLINE, Excerpta Medica Database (EMBASE), Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Literatura Latino Americana em Ciências da Saúde (LILACS) from 1973 (date of the first successful ASO) to February 2014. Identified articles will be screened in duplicate and full text for selected articles will be retrieved. Data extraction will be carried out in duplicate. Discrepancies will be resolved by consensus or by consulting a third author. Where possible, proportions will be pooled using the inverse variance method. Our findings will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-analysis Of Observational studies in Epidemiology (MOOSE) guidelines.
The results of this paper will be disseminated as peer-reviewed publications, at conferences and at clinical rounds. Our findings may answer important questions for surgeons who perform the ASO intervention and for clinicians who take care of patients after surgery and throughout their lifespans.
Prospero/CRD42014007590.
大动脉右位转位（d-TGA）是一种危及生命的先天性健康缺陷，需要迅速进行手术。目前应用最广泛的方法是20世纪70年代由雅泰内开发的动脉调转手术（ASO）。首批接受该手术的儿童现已成年。本综述性文献的目的是记录接受ASO手术儿童的短期（不到1年）、中期（1至20年）和长期（超过20年）结果。我们的主要指标是生存率，但也将探讨其他次要指标，包括手术、心血管、生殖及生活质量方面的结果。
采用系统综述性方法，我们将对已发表文献进行系统检索，查找关于接受ASO手术治疗典型d-TGA儿童的实验性和观察性研究。我们将检索MEDLINE、医学文摘数据库（EMBASE）、护理学与健康相关文献累积索引（CINAHL）以及拉丁美洲健康科学文献数据库（LILACS），检索时间范围为1973年（首例成功ASO手术年份）至2014年2月。检索到的文章将进行双人筛选，选定文章的全文将被获取。数据提取将由两人独立进行。如有分歧，将通过协商或咨询第三位作者解决。如有可能，将采用逆方差法合并比例数据。我们的研究结果将按照系统评价与Meta分析的首选报告项目（PRISMA）以及流行病学观察性研究的Meta分析（MOOSE）指南进行报告。
本文结果将以同行评议出版物的形式、在会议上以及临床查房时进行传播。我们的研究结果可能会为实施ASO手术的外科医生以及术后和患者整个生命周期的护理临床医生解答重要问题。
Prospero/CRD42014007590
