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脑缺血治疗中植物及其成分的综述。

Review of plants and their constituents in the therapy of cerebral ischemia.

机构信息

Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Phytother Res. 2014 Sep;28(9):1265-74. doi: 10.1002/ptr.5187. Epub 2014 Jun 11.

Abstract

Cerebral ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. This leads to cerebral hypoxia and thus to the death of neuronal cells or stroke. The limited number of medicines currently available for patients following ischemic stroke and insufficient data on efficiency of these chemicals in the treatment of stroke led us to the search for novel therapeutic approaches. Recent studies have focused on the possible capacity of natural compounds extracted from vegetables and fruits, to prevent human disabilities caused by cerebral ischemia. In this review, we will discuss some plants and their constituents that may protect brain ischemia or delay the neurological disorders following a stroke. We have reviewed different studies in scientific databases that investigate herbal compounds and their effects on cerebral ischemia.

摘要

脑缺血是指大脑的血液供应不足,无法满足代谢需求的一种情况。这会导致脑缺氧,从而导致神经元细胞死亡或中风。目前,缺血性中风患者可用的药物有限,而且这些药物在中风治疗中的有效性数据也不足,这促使我们寻找新的治疗方法。最近的研究集中在从蔬菜和水果中提取的天然化合物可能预防脑缺血引起的人类残疾的可能性上。在这篇综述中,我们将讨论一些可能预防脑缺血或延迟中风后神经障碍的植物及其成分。我们已经在科学数据库中审查了不同的研究,这些研究调查了草药化合物及其对脑缺血的影响。

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