Lawson Rachael A, Yarnall Alison J, Duncan Gordon W, Khoo Tien K, Breen David P, Barker Roger A, Collerton Daniel, Taylor John-Paul, Burn David J
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
Griffith Health Institute & School of Medicine, Griffith University, Gold Coast, Australia.
J Parkinsons Dis. 2014;4(3):331-6. doi: 10.3233/JPD-140390.
We evaluated the association between mild cognitive impairment (MCI) subtypes and quality of life (QoL) in 219 newly diagnosed Parkinson's disease (PD) patients without dementia. Participants completed neuropsychological tests of attention, executive function, visuospatial function, memory, and language, and reported QoL using the Parkinson's Disease Questionnaire. Impairments were most common in executive function, memory and attention. MCI subtypes were classified according to Movement Disorder Society Task Force criteria. More severe cognitive impairment was associated with poorer quality of life (p = 0.01), but subtype of impairment was not (p > 0.10), suggesting that the nature of cognitive impairment is less significant than its severity.
我们评估了219例新诊断的无痴呆帕金森病（PD）患者的轻度认知障碍（MCI）亚型与生活质量（QoL）之间的关联。参与者完成了注意力、执行功能、视觉空间功能、记忆和语言的神经心理学测试，并使用帕金森病问卷报告了生活质量。执行功能、记忆和注意力方面的损害最为常见。MCI亚型根据运动障碍协会特别工作组的标准进行分类。更严重的认知障碍与较差的生活质量相关（p = 0.01），但损害亚型与生活质量无关（p > 0.10），这表明认知障碍的性质不如其严重程度重要。
