含光学纯无环核苷酸类似物的修饰TBA非对映异构体对抗凝血酶活性的显著影响。
Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue.
作者信息
Scuotto M, Persico M, Bucci M, Vellecco V, Borbone N, Morelli E, Oliviero G, Novellino E, Piccialli G, Cirino G, Varra M, Fattorusso C, Mayol L
机构信息
Dipartimento di Farmacia, via D. Montesano 49, 80131 Napoli, Italy.
出版信息
Org Biomol Chem. 2014 Jul 28;12(28):5235-42. doi: 10.1039/c4ob00149d.
PMID:24920241
Abstract
Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.
摘要
在此，我们报道了光学纯的修饰无环核苷作为适体修饰的理想探针。这些新型单体在探索TBA结构关键位置的单个残基修饰对凝血酶抑制作用中所起的作用方面具有独特优势。
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