Unüvar Tolga, Anık Ahmet, Catlı Gönül, Esen Ihsan, Abacı Ayhan, Büyükgebiz Atilla, Böber Ece
Department of Pediatric Endocrinology, Medical Faculty, Adnan Menderes University, Aydın, 09100, Turkey,
J Endocrinol Invest. 2014 Sep;37(9):799-804. doi: 10.1007/s40618-014-0100-y. Epub 2014 Jun 12.
The aim of the presented study was to evaluate the prevalence of isolated hyperthyrotropinemia (IH) in obese children and the relation between anthropometric and metabolic parameters.
Hospital records of the children, who presented to the Pediatric Endocrinology outpatient clinic of our institution with obesity, and age and gender-matched healthy children, who had undergone thyroid function test for any reason were retrospectively reviewed.
The prevalence of IH was significantly higher in the obese group than in the controls (9.2 and 3.8 %, respectively). Body mass index-standard deviation score (BMI-SDS), thyroid-stimulating hormone (TSH), lipid parameters were significantly different in the obese group than in the control group. A positive correlation between TSH and BMI-SDS and negative correlation between TSH and free T4 (fT4) levels were found in obese subjects. Stepwise multiple linear regression analysis confirmed that BMI-SDS, fT4 and triglyceride levels were the strongest independent variables correlated with TSH level in obese subjects (r (2) = 0.046, p = 0.001).
IH prevalence is higher in obese children as compared to healthy children and the increase in TSH level correlates negatively with serum fT4 and positively with BMI-SDS and triglyceride levels in obese children.
本研究旨在评估肥胖儿童中单纯促甲状腺激素升高（IH）的患病率以及人体测量学参数与代谢参数之间的关系。
回顾性分析我院儿科内分泌门诊就诊的肥胖儿童以及因任何原因接受过甲状腺功能检查的年龄和性别匹配的健康儿童的医院记录。
肥胖组中IH的患病率显著高于对照组（分别为9.2%和3.8%）。肥胖组的体重指数标准差评分（BMI-SDS）、促甲状腺激素（TSH）、血脂参数与对照组相比有显著差异。在肥胖受试者中发现TSH与BMI-SDS呈正相关，TSH与游离T4（fT4）水平呈负相关。逐步多元线性回归分析证实，BMI-SDS、fT4和甘油三酯水平是与肥胖受试者TSH水平相关的最强独立变量（r² = 0.046，p = 0.001）。
与健康儿童相比，肥胖儿童中IH的患病率更高，肥胖儿童中TSH水平的升高与血清fT4呈负相关，与BMI-SDS和甘油三酯水平呈正相关。
