Liang Han, Zhao Qian, Lv Shuangyu, Ji Xinying
The First Affiliated Hospital of Henan University, Henan University, Kaifeng, China.
Institute of Molecular Medicine, Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Front Mol Biosci. 2022 Aug 25;9:956500. doi: 10.3389/fmolb.2022.956500. eCollection 2022.
Phoenixin is a newly discovered neuropeptide generated from small integral membrane protein 20. Phoenixin is a ligand for the G protein-coupled receptor 173 (GPR173) and has been detected in central and peripheral tissues of human, rats, mice, bovine, and zebrafish. It was initially involved in regulating reproductive function by stimulating the luteinizing hormone release from pituitary cells by increasing the level of gonadotropin-releasing hormone. Recently, many functions of phoenixin have been generalized, including regulation of food intake, memory, Alzheimer's disease, anxiety, inflammation, neuronal and microglial activity, energy metabolism and body fluid balance, cardiovascular function, and endocrine activity. In addition, the interaction between phoenixin and nesfatin-1 have been revealed. The present article summarized the latest research progress on physiological function of phoenixin, suggesting that it is a potential target for novel drug development and clinical application.
腓肽是一种新发现的由小整合膜蛋白20产生的神经肽。腓肽是G蛋白偶联受体173（GPR173）的配体，已在人类、大鼠、小鼠、牛和斑马鱼的中枢和外周组织中检测到。它最初通过增加促性腺激素释放激素水平来刺激垂体细胞释放促黄体生成素，从而参与调节生殖功能。最近，腓肽的许多功能已被归纳出来，包括调节食物摄入、记忆、阿尔茨海默病、焦虑、炎症、神经元和小胶质细胞活性、能量代谢和体液平衡、心血管功能以及内分泌活动。此外，还揭示了腓肽与nesfatin-1之间的相互作用。本文总结了腓肽生理功能的最新研究进展，表明它是新型药物开发和临床应用的潜在靶点。
