Galderisi Silvana, Vignapiano Annarita, Mucci Armida, Boutros Nash N
Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138, Naples, NA, Italy,
Curr Top Behav Neurosci. 2014;21:103-28. doi: 10.1007/7854_2014_322.
Patients with schizophrenia have been hypothesized to have a functional impairment in filtering irrelevant sensory information, which may result in positive symptoms such as hallucinations or delusions. Many evidences suggest that abnormalities in the event-related brain potentials (ERPs), resting state electroencephalography (EEG) and synchronized oscillatory activity of neurons may reflect core pathophysiological mechanisms of schizophrenia. Abnormalities in amplitude and latency of the ERPs reflecting aberrations in gating and difficulties in the detection of changes in auditory stimuli, as well as defects in stimuli evaluation and integration of information are common in patients with schizophrenia. This chapter highlights the findings of electrophysiological studies in schizophrenia dealing with early sensory perception and attention, automatic sensory detection of stimuli changes and cognitive evaluation and integration of information, relevant to the pathophysiological mechanisms underpinning hallucinations and delusions. Results of electrophysiological studies investigating the neural correlates of positive symptoms suggest aberrant intrinsic organization of functional brain networks.
有假说认为，精神分裂症患者在过滤无关感觉信息方面存在功能障碍，这可能导致幻觉或妄想等阳性症状。许多证据表明，事件相关脑电位（ERP）、静息态脑电图（EEG）以及神经元同步振荡活动的异常可能反映了精神分裂症的核心病理生理机制。反映门控异常和听觉刺激变化检测困难的ERP波幅和潜伏期异常，以及刺激评估和信息整合缺陷在精神分裂症患者中很常见。本章重点介绍了精神分裂症电生理研究的结果，这些研究涉及早期感觉知觉和注意力、刺激变化的自动感觉检测以及认知评估和信息整合，这些都与幻觉和妄想背后的病理生理机制相关。研究阳性症状神经相关性的电生理研究结果表明功能性脑网络的内在组织异常。
