对青霉素敏感但对头孢菌素敏感性降低的B组链球菌临床分离株。
Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility.
作者信息
Nagano Noriyuki, Nagano Yukiko, Toyama Masami, Kimura Kouji, Shibayama Keigo, Arakawa Yoshichika
机构信息
Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan Medical Microbiology Laboratory, Funabashi Municipal Medical Center, Funabashi, Chiba, Japan.
Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan.
出版信息
J Clin Microbiol. 2014 Sep;52(9):3406-10. doi: 10.1128/JCM.01291-14. Epub 2014 Jun 11.
Abstract
We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTB(r) PSGBS). The CTB(r) PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-binding protein 2X (PBP 2X) and a T567I substitution in PBP 2B, together with an additional G429S substitution in PBP 2X or a T145A substitution in PBP 1A, although the T145A substitution in the transglycosidase domain of PBP 1A would have no effect on the level of resistance to ceftibuten.
摘要
我们对在头孢布烯纸片周围未表现出生长抑制圈的青霉素敏感B组链球菌（PSGBS）临床分离株进行了特征分析（CTB(r) PSGBS）。发现头孢克洛和头孢唑肟的最低抑菌浓度（MIC）增加的CTB(r) PSGBS分离株，在青霉素结合蛋白2X（PBP 2X）中存在T394A替换，在PBP 2B中存在T567I替换，同时在PBP 2X中存在额外的G429S替换或在PBP 1A中存在T145A替换，尽管PBP 1A转糖基酶结构域中的T145A替换对头孢布烯的耐药水平没有影响。
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