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本文引用的文献

1
Ability of the VITEK(R) 2 system to detect group B streptococci with reduced penicillin susceptibility (PRGBS).VITEK(R) 2系统检测青霉素敏感性降低的B组链球菌（PRGBS）的能力。
J Antimicrob Chemother. 2013 Jun;68(6):1442-4. doi: 10.1093/jac/dkt008. Epub 2013 Feb 1.
2
Dominance of serotype Ia among group B Streptococci causing invasive infections in nonpregnant adults in Portugal.葡萄牙导致非孕妇成年人侵袭性感染的 B 群链球菌血清型 Ia 占主导地位。
J Clin Microbiol. 2012 Apr;50(4):1219-27. doi: 10.1128/JCM.05488-11. Epub 2012 Jan 4.
3
Nosocomial spread of multidrug-resistant group B streptococci with reduced penicillin susceptibility belonging to clonal complex 1.医院内传播的青霉素低敏耐多药 B 群链球菌，其属于克隆复合体 1。
J Antimicrob Chemother. 2012 Apr;67(4):849-56. doi: 10.1093/jac/dkr546. Epub 2011 Dec 29.
4
Invasive group B streptococcal infections in adults, France (2007-2010).成人侵袭性 B 组链球菌感染，法国（2007-2010 年）。
Clin Microbiol Infect. 2011 Oct;17(10):1587-9. doi: 10.1111/j.1469-0691.2011.03628.x. Epub 2011 Aug 29.
5
Predominance of sequence type 1 group with serotype VI among group B streptococci with reduced penicillin susceptibility identified in Japan.在日本发现青霉素敏感性降低的 B 组链球菌中，以血清型 VI 为主的 1 型组序列类型占主导地位。
J Antimicrob Chemother. 2011 Nov;66(11):2460-4. doi: 10.1093/jac/dkr352. Epub 2011 Aug 26.
6
Novel mutations in a patient isolate of Streptococcus agalactiae with reduced penicillin susceptibility emerging after long-term oral suppressive therapy.长期口服抑菌治疗后出现的青霉素低敏性无乳链球菌患者分离株中的新型突变。
Antimicrob Agents Chemother. 2011 Jun;55(6):2983-5. doi: 10.1128/AAC.01243-10. Epub 2011 Mar 7.
7
Prosthetic hip joint infection with a Streptococcus agalactiae isolate not susceptible to penicillin G and ceftriaxone.假体髋关节感染，分离出对青霉素G和头孢曲松不敏感的无乳链球菌。
J Antimicrob Chemother. 2010 Mar;65(3):594-5. doi: 10.1093/jac/dkp458. Epub 2009 Dec 18.
8
Molecular characterization of group B streptococci with reduced penicillin susceptibility recurrently isolated from a sacral decubitus ulcer.从骶部褥疮溃疡反复分离出的对青霉素敏感性降低的B组链球菌的分子特征分析
J Antimicrob Chemother. 2009 Dec;64(6):1326-8. doi: 10.1093/jac/dkp374. Epub 2009 Oct 16.
9
Practical disk diffusion test for detecting group B streptococcus with reduced penicillin susceptibility.检测青霉素低敏性 B 群链球菌的实用药敏纸片扩散试验。
J Clin Microbiol. 2009 Dec;47(12):4154-7. doi: 10.1128/JCM.02063-08. Epub 2009 Oct 7.
10
Capsular type and antibiotic resistance in Streptococcus agalactiae isolates from patients, ranging from newborns to the elderly, with invasive infections.从患有侵袭性感染的新生儿至老年人患者中分离出的无乳链球菌菌株的荚膜类型及抗生素耐药性
Antimicrob Agents Chemother. 2009 Jun;53(6):2650-3. doi: 10.1128/AAC.01716-08. Epub 2009 Mar 30.

对青霉素敏感但对头孢菌素敏感性降低的B组链球菌临床分离株。

Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility.

作者信息

Nagano Noriyuki, Nagano Yukiko, Toyama Masami, Kimura Kouji, Shibayama Keigo, Arakawa Yoshichika

机构信息

Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan Medical Microbiology Laboratory, Funabashi Municipal Medical Center, Funabashi, Chiba, Japan.

Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan.

出版信息

J Clin Microbiol. 2014 Sep;52(9):3406-10. doi: 10.1128/JCM.01291-14. Epub 2014 Jun 11.

DOI:10.1128/JCM.01291-14
PMID:24920773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4313170/
Abstract

We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTB(r) PSGBS). The CTB(r) PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-binding protein 2X (PBP 2X) and a T567I substitution in PBP 2B, together with an additional G429S substitution in PBP 2X or a T145A substitution in PBP 1A, although the T145A substitution in the transglycosidase domain of PBP 1A would have no effect on the level of resistance to ceftibuten.

摘要

我们对在头孢布烯纸片周围未表现出生长抑制圈的青霉素敏感B组链球菌（PSGBS）临床分离株进行了特征分析（CTB(r) PSGBS）。发现头孢克洛和头孢唑肟的最低抑菌浓度（MIC）增加的CTB(r) PSGBS分离株，在青霉素结合蛋白2X（PBP 2X）中存在T394A替换，在PBP 2B中存在T567I替换，同时在PBP 2X中存在额外的G429S替换或在PBP 1A中存在T145A替换，尽管PBP 1A转糖基酶结构域中的T145A替换对头孢布烯的耐药水平没有影响。