Crane Frederick L, Löw Hans, Sun Iris, Navas Placido, Gvozdjáková Anna
Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Biologics. 2014 May 29;8:199-205. doi: 10.2147/BTT.S53375. eCollection 2014.
The Voltage Dependent Anion Channel (VDAC) is involved in control of autism. Treatments, including coenzyme Q, have had some success on autism control.
Correlation of porin redox activity and expression of autism is based on extensive literature, especially studies of antibodies, identification of cytosolic nicotinamide adenine dinucleotide reduced (NADH) dehydrogenase activity in the VDAC, and evidence for extreme sensitivity of the dehydrogenase to a mercurial. Evidence for a coenzyme Q requirement came from extraction and analog inhibition of NADH ferricyanide reductase in the erythrocyte plasma membrane, done in 1994, and reinterpreted when it was identified in VDAC in 2004. The effects of ubiquinol (the QH2 - reduced form of coenzyme Q) in children with autism were studied.
A new role for coenzyme Q in the porin channels has implications on autism. Ubiquinol, the more active form of coenzyme Q, produces favorable response in children with autism. Agents which affected electron transport in porin show parallel effects in autism.
We propose a hypothesis that autism is controlled by a coenzyme Q-dependent redox system in the porin channels; this conclusion is based on the effects of agents that positively or negatively affect electron transport and the symptoms of autism. The full understanding of the mechanism of their control needs to be established.
电压依赖性阴离子通道（VDAC）参与自闭症的调控。包括辅酶Q在内的治疗方法在自闭症控制方面已取得一定成效。
孔蛋白氧化还原活性与自闭症表达之间的相关性基于大量文献，特别是关于抗体的研究、VDAC中胞质烟酰胺腺嘌呤二核苷酸还原型（NADH）脱氢酶活性的鉴定，以及该脱氢酶对汞剂极度敏感的证据。辅酶Q需求的证据来自1994年对红细胞质膜中NADH铁氰化物还原酶的提取和类似物抑制研究，并在2004年在VDAC中鉴定出来后进行了重新解读。对泛醇（辅酶Q的还原形式QH2）在自闭症儿童中的作用进行了研究。
辅酶Q在孔蛋白通道中的新作用对自闭症有影响。泛醇，即辅酶Q更具活性的形式，在自闭症儿童中产生了良好的反应。影响孔蛋白中电子传递的物质在自闭症中表现出类似的作用。
我们提出一个假说，即自闭症由孔蛋白通道中依赖辅酶Q的氧化还原系统控制；这一结论基于对电子传递有正向或负向影响的物质的作用以及自闭症的症状。其控制机制的全面理解有待确立。
