Fajardo-Ortiz David, Duran Luis, Moreno Laura, Ochoa Héctor, Castaño Víctor M
Faculty of Medicine of the National Autonomous University of Mexico, Mexico City, Mexico.
El Colegio de la Frontera Sur, San Cristobal de las Casas, Mexico.
Int J Nanomedicine. 2014 May 26;9:2627-34. doi: 10.2147/IJN.S62315. eCollection 2014.
This research maps the knowledge translation process for two different types of nanotechnologies applied to cancer: liposomes and metallic nanostructures (MNs). We performed a structural analysis of citation networks and text mining supported in controlled vocabularies. In the case of liposomes, our results identify subnetworks (invisible colleges) associated with different therapeutic strategies: nanopharmacology, hyperthermia, and gene therapy. Only in the pharmacological strategy was an organized knowledge translation process identified, which, however, is monopolized by the liposomal doxorubicins. In the case of MNs, subnetworks are not differentiated by the type of therapeutic strategy, and the content of the documents is still basic research. Research on MNs is highly focused on developing a combination of molecular imaging and photothermal therapy.
本研究绘制了应用于癌症的两种不同类型纳米技术（脂质体和金属纳米结构）的知识转化过程。我们在受控词汇的支持下对引文网络和文本挖掘进行了结构分析。对于脂质体，我们的结果识别出与不同治疗策略（纳米药理学、热疗和基因治疗）相关的子网络（无形学院）。仅在药理学策略中识别出了有组织的知识转化过程，然而，这一过程被脂质体阿霉素所垄断。对于金属纳米结构，子网络并未根据治疗策略类型进行区分，且文献内容仍为基础研究。金属纳米结构的研究高度集中于开发分子成像和光热治疗的组合。
