妊娠合并乙型肝炎病毒感染所致肝内胆汁淤积症对围产结局的影响。
The impact of intrahepatic cholestasis of pregnancy with hepatitis B virus infection on perinatal outcomes.
机构信息
Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People's Republic of China.
出版信息
Ther Clin Risk Manag. 2014 May 23;10:381-5. doi: 10.2147/TCRM.S61530. eCollection 2014.
INTRODUCTION
To investigate the impact of intrahepatic cholestasis of pregnancy (ICP) with hepatitis B virus (HBV) infection on perinatal outcomes.
METHODS
In the study, 200 pregnant women were divided into four groups, including 50 cases with ICP and HBV infection, 50 cases with ICP, 50 cases with HBV infection, and 50 healthy pregnancies. The delivery process and perinatal outcomes were analyzed among different groups.
RESULTS
When compared to the healthy pregnancy group, significantly increased rates of premature rupture of membranes, meconium-stained amniotic fluid, and cesarean section were observed in cases of ICP, HBV infection, or ICP patients with HBV (P<0.05). Specifically, the rates of HBV infection in the newborn, fetal distress, neonatal asphyxia, and birth defects in the newborn, and infant Apgar scores were higher in ICP pregnancies with HBV (56%, 48%, 16%, and 48%, respectively) than in the other groups (P<0.05).
CONCLUSION
ICP combined with HBV infection has a clear influence on perinatal infant outcomes.
简介
研究目的在于探讨妊娠合并乙型肝炎病毒（HBV）感染的肝内胆汁淤积症（ICP）对围产儿结局的影响。
方法
本研究共纳入 200 例孕妇，将其分为四组，包括 50 例 ICP 合并 HBV 感染、50 例 ICP、50 例 HBV 感染以及 50 例健康妊娠孕妇。分析不同组别孕妇的分娩过程和围产儿结局。
结果
与健康妊娠组相比，ICP、HBV 感染或 ICP 合并 HBV 感染孕妇的胎膜早破、羊水粪染和剖宫产的发生率明显更高（P<0.05）。此外，HBV 感染孕妇的新生儿 HBV 感染率、胎儿窘迫、新生儿窒息和新生儿出生缺陷率以及婴儿 Apgar 评分均更高（56%、48%、16%和 48%）（P<0.05）。
结论
ICP 合并 HBV 感染对围产儿结局有明显影响。
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