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The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume.

作者信息

Eden J A, Place J, Carter G D, Jones J, Alaghband-Zadeh J, Pawson M E

机构信息

Department of Gynecology, Charing Cross Hospital, London, United Kingdom.

出版信息

Obstet Gynecol. 1989 Feb;73(2):187-90.

PMID:2492092
Abstract

Fifteen ovulating women had serial ultrasound scans to measure follicular, endometrial, and uterine growth, as well as biochemical indices including estradiol (E2) and the free androgen index, throughout a natural and a clomiphene-citrate-induced cycle. Despite higher E2 levels in the 5 days preceding ovulation, the clomiphene cycles were characterized by absence of the normal increase in uterine volume and an inhibition of endometrial thickening. It is proposed that the anti-estrogen effect of clomiphene inhibits the normal cyclical growth of the uterus and endometrium.

摘要

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