Bass Plastic Surgery, PLLC, New York, New York.
Plastic & Reconstructive Surgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
Dermatol Surg. 2020 Oct;46 Suppl 1(1):S77-S85. doi: 10.1097/DSS.0000000000002388.
The etiology of cellulite is unclear. Treatment of cellulite has targeted adipose tissue, dermis, and fibrous septae with varying degrees of success and durability of response.
Results from clinical trials that target different anatomical aspects of cellulite can provide insights into the underlying pathophysiology of cellulite.
A search of the PubMed database and ClinicalTrials.gov website was conducted to identify clinical trials that have investigated treatments for cellulite.
A lack of trial protocol standardization, objective means for quantification of improvement and reported cellulite severity, and short-term follow-up, as well as variation in assessment methods have made comparisons among efficacy studies challenging. However, the lack of durable efficacy and inconsistency seen in clinical results suggest that dermal or adipose tissue changes are not the primary etiologies of cellulite. Clinical studies targeting the collagen-rich fibrous septae in cellulite dimples through mechanical, surgical, or enzymatic approaches suggest that targeting fibrous septae is the strategy most likely to provide durable improvement of skin topography and the appearance of cellulite.
The etiology of cellulite has not been completely elucidated. However, there is compelling clinical evidence that fibrous septae play a central role in the pathophysiology of cellulite.
脂肪团的病因尚不清楚。脂肪团的治疗针对脂肪组织、真皮和纤维间隔，在不同程度上取得了成功，并且反应的持久性也不同。
针对脂肪团不同解剖部位的临床试验结果可以深入了解脂肪团的潜在病理生理学。
对 PubMed 数据库和 ClinicalTrials.gov 网站进行了检索，以确定研究脂肪团治疗方法的临床试验。
试验方案缺乏标准化、改善的客观量化手段和报告的脂肪团严重程度、短期随访以及评估方法的差异使得疗效研究之间的比较具有挑战性。然而，缺乏持久疗效和临床结果的不一致性表明，真皮或脂肪组织的变化不是脂肪团的主要病因。针对脂肪团凹痕中富含胶原蛋白的纤维间隔的机械、手术或酶法治疗的临床研究表明，靶向纤维间隔是最有可能提供皮肤轮廓和脂肪团外观持久改善的策略。
脂肪团的病因尚未完全阐明。然而，有强有力的临床证据表明纤维间隔在脂肪团的病理生理学中起着核心作用。
