根据血清 25-羟维生素 D 进行全因死亡率的荟萃分析。
Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D.
机构信息
Cedric F. Garland and Edward D. Gorham are with the Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla. June J. Kim, Sharif B. Mohr, and Kenneth Zeng are with Leidos Biomedical Research, Inc., San Diego. William B. Grant is with Sunlight and Nutrition Research Center, San Francisco, CA. Edward L. Giovannucci is with departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA. Leo Baggerly is with Research Department, GrassrootsHealth, San Diego. Heather Hofflich and Joe W. Ramsdell are with Internal Medicine Group, Department of Medicine, University of California San Diego. Robert P. Heaney is with Department of Medicine, Creighton University, Omaha, NE.
出版信息
Am J Public Health. 2014 Aug;104(8):e43-50. doi: 10.2105/AJPH.2014.302034. Epub 2014 Jun 12.
We examined the relationship between serum 25-hydroxyvitamin D (25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 or more categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for all-cause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P < .001). Serum 25(OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-cause mortality than concentrations greater than 30 ng/mL (P < .01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.
我们研究了血清 25-羟维生素 D（25[OH]D）与全因死亡率之间的关系。我们检索了生物医学数据库中评估血清 25（OH）D 两个或更多分类的文章，时间范围为 1966 年 1 月 1 日至 2013 年 1 月 15 日。我们确定了 32 项研究，并对数据进行了汇总。比较血清 25（OH）D 最低（0-9 纳克/毫升[ng/mL]）和最高（>30 ng/mL）范围的全因死亡率的危险比为 1.9（95%置信区间为 1.6, 2.2；P<.001）。血清 25（OH）D 浓度等于或小于 30 ng/mL 与大于 30 ng/mL 的浓度相比，与更高的全因死亡率相关（P<.01）。我们的发现与美国国家科学院的一份报告一致，但本分析中全因死亡率降低的截止点大于 30 ng/mL，而不是大于 20 ng/mL。
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