免疫组化证据表明 ghrelin 表达与食管癌肿瘤生长之间存在关联。
Immunohistochemical evidence of association between ghrelin expression and tumor growth in esophageal carcinoma.
机构信息
Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
出版信息
Anticancer Res. 2014 Jun;34(6):2727-33.
BACKGROUND
Ghrelin, an orexigenic peptide, is primarily produced and secreted by the gastrointestinal tract. As far as we are aware of, there is no evidence of ghrelin expression in esophageal squamous cell carcinoma (ESCC).
MATERIALS AND METHODS
Two hundred and ten patients with ESCC who underwent surgical resection were enrolled in this study. We immunohistochemically investigated ghrelin expression in primary ESCC specimens and analyzed the relationship with clinicopathological factors.
RESULTS
High ghrelin expression was observed in 61 patients (29.0%). Depth of tumor invasion and histological differentiation were statistically associated with ghrelin expression. As for depth of tumor invasion, the deeper it was, the higher was the expression of ghrelin. Well-differentiated tumors had a significantly higher proportion of ghrelin-expressing cells than other types.
CONCLUSION
Ghrelin expression correlated with tumor depth and tumor differentiation, suggesting an important role of ghrelin in tumor growth in ESCC.
背景
Ghrelin 是一种促食欲肽，主要由胃肠道产生和分泌。据我们所知，食管鳞状细胞癌（ESCC）中没有 ghrelin 表达的证据。
材料与方法
本研究纳入了 210 例接受手术切除的 ESCC 患者。我们通过免疫组织化学方法检测了原发性 ESCC 标本中 ghrelin 的表达，并分析了其与临床病理因素的关系。
结果
61 例（29.0%）患者 ghrelin 表达较高。肿瘤浸润深度和组织学分化与 ghrelin 表达呈统计学相关。就肿瘤浸润深度而言，ghrelin 的表达越高，肿瘤浸润越深。高分化肿瘤 ghrelin 表达细胞的比例明显高于其他类型。
结论
Ghrelin 的表达与肿瘤深度和肿瘤分化相关，提示 ghrelin 在 ESCC 肿瘤生长中具有重要作用。
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