Department of Thoracic Surgery, Hamanomachi General Hospital, Fukuoka, Japan.
Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Anticancer Res. 2014 Jun;34(6):3053-9.
Recently N(1),N(12)-diacetylspermine, a diacetylated polyamine derivative, was recognized as a tumor marker in patients with several kinds of cancers. However, the significance of its levels in urine as a prognostic factor has not been elucidated. In the present study, we examined whether the urine N(1),N(12)-diacetylspermine levels can be used as a prognostic factor in patients with NSCLC.
Urine samples from 251 patients with NSCLC were collected prior to surgery and the urinary N(1),N(12)-diacetylspermine concentration was measured. Thereafter, all 251 patients underwent curative surgery and the analysis of prognosis was performed for over 10 years. Out of the 251 patients, 91 had recurrent disease. The significance of the urinary N(1),N(12)-diacetylspermine level as a prognostic factor among all 251 patients and among the 91 patients with recurrence was evaluated.
Univariate analysis of all 251 patients showed that the level of urinary N(1),N(12)-diacetylspermine was a significant prognostic factor for disease-free survival and overall survival; however, multivariate analysis showed it had no significance. Conversely, the univariate and multivariate analyses of post-recurrent survival of the 91 patients with recurrence showed that urinary N(1),N(12)-diacetylspermine was an independent prognostic factor for post-recurrent survival.
Patients with recurrence with positive urinary N(1),N(12)-diacetylspermine should undergo more intensive care and determination of urinary N(1),N(12)-diacetylspermine may contribute to improvement of prognosis of NSCLC.
最近，N(1)，N(12)-二乙酰基精脒，一种二乙酰化多胺衍生物，被认为是多种癌症患者的肿瘤标志物。然而，其在尿液中的水平作为预后因素的意义尚未阐明。在本研究中，我们研究了尿 N(1)，N(12)-二乙酰基精脒水平是否可以作为非小细胞肺癌患者的预后因素。
收集了 251 例非小细胞肺癌患者手术前的尿液样本，并测量了尿 N(1)，N(12)-二乙酰基精脒浓度。此后，所有 251 例患者均接受了根治性手术，并对超过 10 年的预后进行了分析。在 251 例患者中，91 例出现复发。评估了尿 N(1)，N(12)-二乙酰基精脒水平作为所有 251 例患者和 91 例复发患者的预后因素的意义。
对所有 251 例患者进行的单因素分析显示，尿 N(1)，N(12)-二乙酰基精脒水平是疾病无进展生存和总生存的显著预后因素；然而，多因素分析显示其无意义。相反，91 例复发患者的复发后生存的单因素和多因素分析显示，尿 N(1)，N(12)-二乙酰基精脒是复发后生存的独立预后因素。
尿 N(1)，N(12)-二乙酰基精脒阳性的复发患者应接受更密集的护理，尿 N(1)，N(12)-二乙酰基精脒的测定可能有助于改善非小细胞肺癌的预后。
