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一碳和多胺代谢作为癌症治疗靶点。

One-Carbon and Polyamine Metabolism as Cancer Therapy Targets.

机构信息

College of Medicine and Public Health, Flinders University, Adelaide 5042, Australia.

Clinical and Health Sciences, University of South Australia, Adelaide 5001, Australia.

出版信息

Biomolecules. 2022 Dec 19;12(12):1902. doi: 10.3390/biom12121902.

DOI:10.3390/biom12121902
PMID:36551330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9775183/
Abstract

Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid replication. A common target of this metabolic reprogramming is one-carbon metabolism which is notable for its function in DNA synthesis, protein and DNA methylation, and antioxidant production. Polyamines are a key output of one-carbon metabolism with widespread effects on gene expression and signaling. As a result of these functions, one-carbon and polyamine metabolism have recently drawn a lot of interest for their part in cancer malignancy. Therapeutic inhibitors that target one-carbon and polyamine metabolism have thus been trialed as anticancer medications. The significance and future possibilities of one-carbon and polyamine metabolism as a target in cancer therapy are discussed in this review.

摘要

癌症代谢重编程对于维持癌细胞的存活和快速复制至关重要。这种代谢重编程的一个常见目标是一碳代谢，其功能主要体现在 DNA 合成、蛋白质和 DNA 甲基化以及抗氧化剂的产生。多胺是一碳代谢的关键产物，对基因表达和信号转导有广泛的影响。由于这些功能，一碳和多胺代谢最近因其在癌症恶性肿瘤中的作用而引起了广泛关注。因此，靶向一碳和多胺代谢的治疗抑制剂已被尝试作为抗癌药物。本文综述了一碳和多胺代谢作为癌症治疗靶点的意义和未来可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/360a/9775183/0e47c1bc9b81/biomolecules-12-01902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/360a/9775183/0e47c1bc9b81/biomolecules-12-01902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/360a/9775183/0e47c1bc9b81/biomolecules-12-01902-g001.jpg

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[2]
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[3]
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Polyamine metabolism and anti-tumor immunity.

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[5]
Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients.

J Cancer Res Clin Oncol. 2024-10-23

[6]
Metabolic adaptations in prostate cancer.

Br J Cancer. 2024-11

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[8]
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[9]
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[10]
Positive Association of Serum Vitamin B6 Levels with Intrapulmonary Lymph Node and/or Localized Pleural Metastases in Non-Small Cell Lung Cancer: A Retrospective Study.

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本文引用的文献

[1]
The Impact of Homocysteine on the Risk of Hormone-Related Cancers: A Mendelian Randomization Study.

Front Nutr. 2021-8-24

[2]
Simultaneous Determination of Polyamines and Steroids in Human Serum from Breast Cancer Patients Using Liquid Chromatography-Tandem Mass Spectrometry.

Molecules. 2021-2-21

[3]
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil.

Cancer Res. 2021-5-1

[4]
Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective.

Int J Mol Sci. 2020-7-25

[5]
Oxidative Stress in Cancer.

Cancer Cell. 2020-8-10

[6]
Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition.

Biomolecules. 2020-4-30

[7]
MTHFD1L-Mediated Redox Homeostasis Promotes Tumor Progression in Tongue Squamous Cell Carcinoma.

Front Oncol. 2019-12-5

[8]
Methionine metabolism in health and cancer: a nexus of diet and precision medicine.

Nat Rev Cancer. 2019-9-12

[9]
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.

Mol Cell. 2019-8-29

[10]
Distinct methylation levels of mature microRNAs in gastrointestinal cancers.

Nat Commun. 2019-8-29

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