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克隆的曼氏血吸虫蛋白酶（血红蛋白酶）作为一种潜在的血清学诊断试剂。

Cloned Schistosoma mansoni proteinase (hemoglobinase) as a putative serodiagnostic reagent.

作者信息

Chappell C L, Hackel J, Davis A H

机构信息

Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030.

出版信息

J Clin Microbiol. 1989 Jan;27(1):196-8. doi: 10.1128/jcm.27.1.196-198.1989.

DOI:10.1128/jcm.27.1.196-198.1989
PMID:2492298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC267263/
Abstract

Expressed cDNA encoding a proteolytic enzyme from Schistosoma mansoni has been cloned recently. Circulating antibodies reacting with the recombinant protein have been detected in the blood of mice and humans infected with S. mansoni, S. japonicum, or S. haematobium. S. mansoni and S. haematobium infection can be distinguished by antibody titer.

摘要

最近克隆出了编码曼氏血吸虫一种蛋白水解酶的cDNA。在感染曼氏血吸虫、日本血吸虫或埃及血吸虫的小鼠和人类血液中检测到了与重组蛋白发生反应的循环抗体。曼氏血吸虫感染和埃及血吸虫感染可通过抗体滴度加以区分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/267263/0465a8090e07/jcm00061-0221-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/267263/04e99fcc5238/jcm00061-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/267263/0465a8090e07/jcm00061-0221-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/267263/04e99fcc5238/jcm00061-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc66/267263/0465a8090e07/jcm00061-0221-b.jpg

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本文引用的文献

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Schistosome Antigen Laboratory Workshop: summary of a meeting sponsored by the Edna McConnell Clark Foundation.
J Parasitol. 1983 Feb;69(1):45-8.
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Immunoblot analysis of Schistosoma mansoni antigens with sera of schistosomiasis patients: diagnostic potential of an adult schistosome polypeptide.用血吸虫病患者血清对曼氏血吸虫抗原进行免疫印迹分析：一种成年血吸虫多肽的诊断潜力
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[Molecular biological techniques in the diagnosis of tropical parasitic diseases].[热带寄生虫病诊断中的分子生物学技术]
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Cloning and gene expression of Schistosoma mansoni protease.
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Antibody response to a purified parasite proteinase (SMw32) in Schistosoma mansoni infected mice.曼氏血吸虫感染小鼠对纯化寄生虫蛋白酶（SMw32）的抗体反应。
Am J Trop Med Hyg. 1988 Jul;39(1):66-73. doi: 10.4269/ajtmh.1988.39.66.
7
Expression of diagnostic 31/32 kilodalton proteins of Schistosoma mansoni as fusions with bacteriophage MS2 polymerase.曼氏血吸虫诊断性31/32千道尔顿蛋白与噬菌体MS2聚合酶融合体的表达
Mol Biochem Parasitol. 1988 Jan 15;27(2-3):233-9. doi: 10.1016/0166-6851(88)90042-4.
8
Schistosoma mansoni: anti-SMw32 proteinase response in vaccinated and challenged baboons.
Am J Trop Med Hyg. 1987 Sep;37(2):320-6. doi: 10.4269/ajtmh.1987.37.320.
9
Antibodies of patients infected with Schistosoma japonicum crossreact with diagnostic proteins of Schistosoma mansoni.
J Tongji Med Univ. 1986;6(3):138-43. doi: 10.1007/BF02911449.