Kim Ha-Na, Kim Se-Hong, Song Sang-Wook
Department of Family medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of Korea.
Kidney Blood Press Res. 2014;39(1):40-9. doi: 10.1159/000355775. Epub 2014 Jun 3.
BACKGROUND/AIMS: We examined relationships between the average amount of daily alcohol intake, drinking patterns, and renal dysfunction among South Korean adultsaged ≥ 20 years.
The analysis used data from the Korean National Health and Nutrition Examination Survey (KNHANES), a cross-sectional survey of Korean civilians, conducted from January to December 2011. In this study, a sample of 5,251 participants was analysed.
Compared with abstinence, the odds ratio for a decrease in estimated glomerular filtration rate (eGFR) was 0.14 (95% CI: 0.01-0.91) among heavy drinkers, and 0.42 (95% CI: 0.17-0.98) among binge drinkers and the association between the amount of mean daily alcohol intake, binge-drinking status and a likelihood of reduced eGFR value showed significant trends (p = 0.041 and p = 0.038, respectively), after adjusting for age, smoking status, amount of physical activity, morbid hypertension, diabetes, dyslipidaemia, anaemia and body mass index. There was no significant association between alcohol consumption and the urine albumin to creatinine ratio in men, or between alcohol consumption and renal dysfunction in women.
Alcohol consumption was inversely associated with a reduction in eGFR in Korean men. However, these findings should be interpreted cautiously, given the other harmful effects related to alcohol consumption, especially heavy and binge drinking.
背景/目的：我们研究了年龄≥20岁的韩国成年人每日酒精摄入量、饮酒模式与肾功能不全之间的关系。
分析采用了韩国国家健康与营养检查调查（KNHANES）的数据，这是一项对韩国平民进行的横断面调查，于2011年1月至12月进行。本研究分析了5251名参与者的样本。
与戒酒者相比，在调整年龄、吸烟状况、身体活动量、病态高血压、糖尿病、血脂异常、贫血和体重指数后，重度饮酒者估计肾小球滤过率（eGFR）降低的比值比为0.14（95%置信区间：0.01 - 0.91），暴饮者为0.42（95%置信区间：0.17 - 0.98），且平均每日酒精摄入量、暴饮状态与eGFR值降低可能性之间的关联呈现显著趋势（分别为p = 0.041和p = 0.038）。男性饮酒量与尿白蛋白肌酐比值之间，以及女性饮酒量与肾功能不全之间均无显著关联。
在韩国男性中，饮酒与eGFR降低呈负相关。然而，鉴于与饮酒相关的其他有害影响，尤其是重度饮酒和暴饮，这些发现应谨慎解读。
