Division of Endocrinology and Metabolism, Department of Internal Medicine, Puli Branch of Taichung Veterans General Hospital, Nantou 54552, Taiwan.
School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Nutrients. 2019 Sep 6;11(9):2121. doi: 10.3390/nu11092121.
Alcohol consumption is a significant public health issue worldwide. The rat model and epidemiological studies have both reported conflicting results about the effects of alcohol on the kidneys. We aimed to explore the relationships between alcohol consumption and chronic kidney disease. Data from the National Health Interview Survey, the National Health Insurance research database, and the National Deaths Dataset were used. Standardized in-person interviews were executed in 2001, 2005, and 2009 to obtain the demographic characteristics of study population. The participants were followed up until 2013. The primary outcome was new-onset chronic kidney disease. We analyzed 45,200 adults older than 18 years (50.8% men and 49.2% women), and the overall mean (SD) age was 42.73 (16.64) years. During the 8.5 (3.5) years of follow-up, new-onset chronic kidney disease was recognized in 1535 (5.5%), 292 (2.7%), and 317 (4.9%) non-drinking, social-drinking, and regular-drinking participants, respectively. The participants who were social and regular drinkers had a significantly decreased risk of chronic kidney disease incidence (social drinking: adjusted hazard ratio (HR), 0.85; 95% confidence interval (CI), 0.74-0.97; = 0.018; regular-drinking: AHR, 0.85; 95% CI, 0.74-0.98; = 0.024), with baseline demographics and comorbidities adjusted. In conclusion, social and regular drinkers had decreased risk of chronic kidney disease when compared with non-drinkers.
饮酒是全球范围内一个重大的公共卫生问题。大鼠模型和流行病学研究都报告了酒精对肾脏影响的相互矛盾的结果。我们旨在探讨饮酒与慢性肾脏病之间的关系。本研究使用了来自全国健康访谈调查、全国健康保险研究数据库和全国死亡数据集的数据。2001 年、2005 年和 2009 年进行了标准化的面对面访谈，以获取研究人群的人口统计学特征。参与者随访至 2013 年。主要结局是新诊断的慢性肾脏病。我们分析了 45200 名年龄在 18 岁以上的成年人（50.8%为男性，49.2%为女性），总体平均（SD）年龄为 42.73（16.64）岁。在 8.5（3.5）年的随访期间，分别有 1535 名（5.5%）、292 名（2.7%）和 317 名（4.9%）非饮酒者、社交饮酒者和规律饮酒者新诊断为慢性肾脏病。与非饮酒者相比，社交饮酒者和规律饮酒者发生慢性肾脏病的风险显著降低（社交饮酒：调整后的危害比（HR），0.85；95%置信区间（CI），0.74-0.97； = 0.018；规律饮酒：AHR，0.85；95%CI，0.74-0.98； = 0.024），调整了基线人口统计学和合并症。总之，与非饮酒者相比，社交饮酒者和规律饮酒者发生慢性肾脏病的风险降低。
